Trial reportTheoretical biology & medical modelling2011
A simple intravenous glucose tolerance test for assessment of insulin sensitivity.
Trial report in Theoretical biology & medical modelling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Dipeptidyl-Peptidase-IV Inhibitors, Imigliptin and Alogliptin, Improve Beta-Cell Function in Type 2 Diabetes.Frontiers in endocrinology · 2021Trial
- Effects of substituting eggs for high-carbohydrate breakfast foods on the cardiometabolic risk-factor profile in adults at risk for type 2 diabetes mellitus.European journal of clinical nutrition · 2020Trial
- Plasma volume expansion from the intravenous glucose tolerance test before and after hip replacement surgery.Theoretical biology & medical modelling · 2013Trial
- Oral nutrition or water loading before hip replacement surgery; a randomized clinical trial.Trials · 2012Trial
- Alterations in Skeletal Muscle Insulin Signaling DNA Methylation: A Pilot Randomized Controlled Trial of Olanzapine in Healthy Volunteers.Biomedicines · 2024Article
- SPINA Carb: a simple mathematical model supporting fast in-vivo estimation of insulin sensitivity and beta cell function.Scientific reports · 2022Article
- Glucoregulation and coping behavior after chronic stress in rats: Sex differences across the lifespan.Hormones and behavior · 2021Article
- Comparison of measures of insulin sensitivity in early-lactation dairy goats.JDS communications · 2021Article
- Alkaloidal extract fromHeliyon · 2021Article
- Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes.PloS one · 2019Observational
- Consistency of compact and extended models of glucose-insulin homeostasis: The role of variable pancreatic reserve.PloS one · 2019Article
- Cats and Carbohydrates: The Carnivore Fantasy?Veterinary sciences · 2017Review
- High Intensity Aerobic Exercise Training Improves Deficits of Cardiovascular Autonomic Function in a Rat Model of Type 1 Diabetes Mellitus with Moderate Hyperglycemia.Journal of diabetes research · 2016Article
- How fast can glucose be infused in the perioperative setting?Perioperative medicine (London, England) · 2016Article
- Relationship between thioredoxin-interacting protein (TXNIP) and islet β-cell dysfunction in patients with impaired glucose tolerance and hypertriglyceridemia.International journal of clinical and experimental medicine · 2015Article
- Normal glucose metabolism in carnivores overlaps with diabetes pathology in non-carnivores.Frontiers in endocrinology · 2013Review
- Preoperative insulin resistance reduces complications after hip replacement surgery in non-diabetic patients.BMC anesthesiology · 2013Article
- Plasma volume expansion resulting from intravenous glucose tolerance test.Computational and mathematical methods in medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the study was to find a simple intravenous glucose tolerance test (IVGTT) that can be used to estimate insulin sensitivity.
methodsIn 20 healthy volunteers aged between 18 and 51 years (mean, 28) comparisons were made between kinetic parameters derived from a 12-sample, 75-min IVGTT and the M(bw) (glucose uptake) obtained during a hyperinsulinemic euglycemic glucose clamp. Plasma glucose was used to calculate the volume of distribution (V(d)) and the clearance (CL) of the injected glucose bolus. The plasma insulin response was quantified by the area under the curve (AUC(ins)). Uptake of glucose during the clamp was corrected for body weight (M(bw)).
resultsThere was a 7-fold variation in M(bw). Algorithms based on the slope of the glucose-elimination curve (CL/V(d)) in combination with AUC(ins) obtained during the IVGTT showed statistically significant correlations with M(bw), the linearity being r(2) = 0.63-0.83. The best algorithms were associated with a 25-75th prediction error ranging from -10% to +10%. Sampling could be shortened to 30-40 min without loss of linearity or precision.
conclusionSimple measures of glucose and insulin kinetics during an IVGTT can predict between 2/3 and 4/5 of the insulin sensitivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.