Evidence map›Paper›PMID 21535390›Full record

ArticleJournal of thrombosis and haemostasis : JTH2011

Use and outcomes of venous thromboembolism prophylaxis after spinal fusion surgery.

M C Fang, J Maselli, J D Lurie, P K Lindenauer, P S Pekow, A D Auerbach

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Analysis of risk factors for deep vein thrombosis after lumbar endoscopic single-segment decompression without fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Trends in comorbidity, acuity, and maternal risk associated with preeclampsia across obstetric volume settings.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

M C FangDivision of Hospital Medicine, The University of California San Francisco, CA, USA. mfang@medicine.ucsf.edu
J Maselli
J D Lurie
P K Lindenauer
P S Pekow
A D Auerbach
University of California, San Francisco · USBaystate Medical Center · USDartmouth Institute for Health Policy and Clinical Practice · USTufts University · US

Funding

Improving management of cardiovascular medications during hospitalizationK24HL098372 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AUERBACH, ANDREW D · 2010 to 2014
$887k
Risks of Warfarin for Elders with Atrial FibrillationK23AG028978 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FANG, MARGARET C. · 2006 to 2010
$866k
NHLBI NIH HHS K24 HL098372NIA NIH HHS K23 AG028978
6 · The paper itself

Abstract

backgroundThe number of spinal fusion operations in the USA is rapidly rising, but little is known about optimal venous thromboembolism prophylaxis after spinal surgery.

objectivesTo examine the use of and outcomes associated with venous thromboembolism prophylaxis after spinal fusion surgery in a cohort of 244 US hospitals. PATIENTS/

methodsWe identified all patients with a principal procedure code for spinal fusion surgery in hospitals participating in the Premier Perspective database from 2003 to 2005, and searched for receipt of pharmacologic prophylaxis (subcutaneous unfractionated heparin, low molecular weight heparin, or fondaparinux) and/or mechanical prophylaxis (compression devices and elastic stockings) within the first 7 days after surgery. We also searched for discharge diagnosis codes for venous thromboembolism and postoperative hemorrhage during the index hospitalization and within 30 days after surgery.

resultsAmong 80,183 spinal fusions performed during the time period, cervical fusions were the most common (49.0%), followed by lumbar fusions (47.8%). Thromboembolism prophylaxis was administered to 60.6% of patients within the first week postoperatively, with the most frequent form being mechanical prophylaxis alone (47.6%). Of the 244 hospitals, 26.2% provided prophylaxis to ≥ 90% of their patients undergoing spinal fusion; however, 33.2% provided prophylaxis to fewer than 50% of their patients. The rate of diagnosed venous thromboembolism within 30 days after surgery was 0.45%, and the rate of postoperative hemorrhage was 1.1%.

conclusionsSubstantial variation exists in the use of thromboembolism prophylaxis after spinal fusion surgery in the USA. Nevertheless, overall rates of diagnosed thromboembolism after spinal fusion appear to be low.

Indexed as

AdultAgedChemopreventionCohort StudiesDatabases, FactualFemaleFondaparinuxHemorrhageHeparinHumansMaleMiddle AgedPolysaccharidesPostoperative ComplicationsRetrospective StudiesSpinal FusionFondaparinuxHeparinPolysaccharides

Identifiers

PMID21535390
PMCPMC3129495
OpenAlexW1483994619

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.