ArticleMolecular ecology2011
Divergent transcriptional response to thermal stress by Anopheles gambiae larvae carrying alternative arrangements of inversion 2La.
Article in Molecular ecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Local trait responses and aquatic microclimates increase projected habitat suitability for field-collectedbioRxiv : the preprint server for biology · 2026Article
- Regional transcriptomic divergence reveals thermal adaptation mechanisms in the giant kelp Macrocystis pyrifera.Scientific reports · 2026Article
- Spatial eco-climatic gradients drive adaptive 2La chromosomal inversion polymorphism in Anopheles coluzzii, a major malaria vector in Nigeria.International journal of health geographics · 2026Article
- Spatial distribution of the 2La chromosomal inversion in Anopheles gambiae populations across Nigeria: ecological associations and implications for malaria control.Tropical medicine and health · 2026Article
- Article
- Thermal variation influences the transcriptome of the major malaria vector Anopheles stephensi.Communications biology · 2025Article
- A novel tetra-primer ARMS-PCR approach for the molecular karyotyping of chromosomal inversion 2Ru in the main malaria vectors Anopheles gambiae and Anopheles coluzzii.Parasites & vectors · 2023Article
- GeCoNet-Tool: a software package for gene co-expression network construction and analysis.BMC bioinformatics · 2023Article
- Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector Anopheles coluzzii.BMC biology · 2023Article
- A globalBMC bioinformatics · 2022Article
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- Molecular evolution and the decline of purifying selection with age.Nature communications · 2021Article
- Profile of Nora J. Besansky.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- High-Throughput Genotyping of Common Chromosomal Inversions in the Afrotropical Malaria MosquitoInsects · 2020Article
- Inversion Genotyping in theG3 (Bethesda, Md.) · 2020Article
- Highly specific PCR-RFLP assays for karyotyping the widespread 2Rb inversion in malaria vectors of the Anopheles gambiae complex.Parasites & vectors · 2020Article
- In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in theG3 (Bethesda, Md.) · 2019Article
- Association mapping desiccation resistance within chromosomal inversions in the African malaria vector Anopheles gambiae.Molecular ecology · 2019Article
- Systems genetic analysis of inversion polymorphisms in the malaria mosquitoProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Environmental Plasticity in the Intersexual Correlation and Sex Bias of Gene Expression.The Journal of heredity · 2017Article
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6 authors.
Funding
Abstract
The African malaria mosquito Anopheles gambiae is polymorphic for chromosomal inversion 2La, whose frequency strongly correlates with degree of aridity across environmental gradients. Recent physiological studies have associated 2La with resistance to desiccation in adults and thermal stress in larvae, consistent with its proposed role in aridity tolerance. However, the genetic basis of these traits remains unknown. To identify genes that could be involved in the differential response to thermal stress, we compared global gene expression profiles of heat-hardened 2La or 2L+(a) larvae at three time points, for up to eight hours following exposure to the heat stress. Treatment and control time series, replicated four times, revealed a common and massive induction of a core set of heat-shock genes regardless of 2La orientation. However, clear differences between the 2La and 2L+(a) arrangements emerged at the earliest (0.25 h) time point, in the intensity and nature of the stress response. Overall, 2La was associated with the more aggressive response: larger numbers of genes were heat responsive and up-regulated. Transcriptionally induced genes were enriched for functions related to ubiquitin-proteasomal degradation, chaperoning and energy metabolism. The more muted transcriptional response of 2L+(a) was largely repressive, including genes involved in proteolysis and energy metabolism. These results may help explain the maintenance of the 2La inversion polymorphism in An. gambiae, as the survival benefits offered by high thermal sensitivity in harsh climates could be offset by the metabolic costs of such a drastic response in more equable climates.
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