ArticleDiabetologia2011
The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes.
Article in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between type 1 diabetes mellitus and dental caries in children and adolescents: a meta-analysis and Mendelian randomization study.Frontiers in endocrinology · 2026Pooled it
- Systematic Review of Polygenic Risk Scores for Type 1 and Type 2 Diabetes.International journal of molecular sciences · 2020Pooled it
- Partitioning genetic effects on birthweight at classical human leukocyte antigen loci into maternal and fetal components, using structural equation modelling.International journal of epidemiology · 2024Article
- Next-generation sequencing reveals additional HLA class I and class II alleles associated with type 1 diabetes and age at onset.Frontiers in immunology · 2024Article
- Circulating β cell-specific CD8Clinical and experimental immunology · 2020Article
- Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC.Diabetes care · 2020Article
- Clinical and research uses of genetic risk scores in type 1 diabetes.Current opinion in genetics & development · 2018Review
- HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- HLA class I and II alleles are associated with microvascular complications of type 1 diabetes.Human immunology · 2013Article
- Genetics of type 1 diabetes.Cold Spring Harbor perspectives in medicine · 2012Review
- Development of a quantitative methylation-specific polymerase chain reaction method for monitoring beta cell death in type 1 diabetes.PloS one · 2012Article
- Genetics of the HLA region in the prediction of type 1 diabetes.Current diabetes reports · 2011Review
- The past, present, and future of genetic associations in type 1 diabetes.Current diabetes reports · 2011Review
- Prevention of type 1A diabetes mellitus.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsReview
- HLA-B Matching Prolongs Allograft Survival in Islet Cell Transplantation.Cell transplantationArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aims/hypothesisWe investigated the risk associated with HLA-B*39 alleles in the context of specific HLA-DR/DQ haplotypes.
methodsWe studied a readily available dataset from the Type 1 Diabetes Genetics Consortium that consists of 2,300 affected sibling pair families genotyped for both HLA alleles and 2,837 single nucleotide polymorphisms across the major histocompatibility complex region.
resultsThe B*3906 allele significantly enhanced the risk of type 1 diabetes when present on specific HLA-DR/DQ haplotypes (DRB1 0801-DQB1 0402: p = 1.6 × 10(-6), OR 25.4; DRB1 0101-DQB1 0501: p = 4.9 × 10(-5), OR 10.3) but did not enhance the risk of DRB1 0401-DQB1 0302 haplotypes. In addition, the B 3901 allele enhanced risk on the DRB1 1601-DQB1 0502 haplotype (p = 3.7 × 10(-3), OR 7.2). CONCLUSIONS/
interpretationThese associations indicate that the B 39 alleles significantly increase risk when present on specific HLA-DR/DQ haplotypes, and HLA-B typing in concert with specific HLA-DR/DQ genotypes should facilitate genetic prediction of type 1 diabetes, particularly in a research setting.
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