Evidence map›Paper›PMID 21533575›Full record

ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2011

Diffuse intrinsic pontine glioma-current status and future strategies.

Soumen Khatua, Kevin R Moore, Tribh S Vats, John R W Kestle

Abstract readReview
PubMed Publisher
In one paragraph

Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Radiotherapy for diffuse brainstem glioma in children and young adults.The Cochrane database of systematic reviews · 2016
    Pooled it
  2. Article
  3. Contemporary Management of Pediatric Brainstem Tumors.Advances and technical standards in neurosurgery · 2024
    Review
  4. European journal of nuclear medicine and molecular imaging · 2023
    Article
  5. Observational
  6. Article
  7. Review
  8. Article
  9. Article
  10. Novel drugs in pediatric gliomas.Oncology letters · 2017
    Article
  11. Convection-Enhanced Delivery.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017
    Review
  12. Pre-radiation chemotherapy improves survival in pediatric diffuse intrinsic pontine gliomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016
    Article
  13. Article
  14. Biopsy in a series of 130 pediatric diffuse intrinsic Pontine gliomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015
    Article
  15. Article
  16. Toxicity evaluation of prolonged convection-enhanced delivery of small-molecule kinase inhibitors in naïve rat brainstem.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015
    Article
  17. Article
  18. Article
  19. Article
  20. Transcerebellar biopsy of diffuse pontine gliomas in children: a technical note.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Soumen KhatuaPediatric Neurooncology, Children's Cancer Hospital, MD Anderson Cancer Center, Houston, TX 77030, USA. skhatua@mdanderson.org
Kevin R Moore
Tribh S Vats
John R W Kestle

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDiffuse intrinsic pontine gliomas which constitute 15% of all childhood brain tumors are inoperable and response to radiation and chemotherapy has not improved long-term survival. Due to lack of newer effective therapies, mean survival after diagnosis has remained less than 12 months. Trials investigating chemotherapy and/or radiation have proven disappointing. As biopsy of these tumors are rarely performed due to the high eloquence of the brain stem, information about the pathology and biology remains elusive hindering development of novel biologic agents. Poor access of most chemotherapeutic agents to these tumors due to the blood-brain barrier continues to undermine therapeutic efficacy. Thus, to date, we remain at a virtual standstill in our attempts to improve the prognosis of children with these tumors.

methodsAn extensive review of the literature was performed concerning children with diffuse brain stem gliomas including clinical trials, evolving molecular biology, and newer therapeutic endeavors.

conclusionA pivotal approach in improving the prognosis of these tumors should include the initiation of biopsy and encouraging families to consider autopsy to study the molecular biology. This will help in redefining this tumor by its molecular signature and profiling targeted therapy. Continued advances should be pursued in neuroimaging technology including identifying surrogate markers of early disease progression. Defining strategies to enhance local delivery of drugs into tumors with the help of newer surgical techniques are important. Exhaustive research in all these aspects as a multidisciplinary approach could provide hope to children with these fatal tumors.

Indexed as

Brain Stem NeoplasmsChildHumansNeuroimagingPons

Identifiers

PMID21533575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.