ArticleIntensive care medicine2011
Do centrally pre-prepared solutions achieve more reliable drug concentrations than solutions prepared on the ward?
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Systematic evidence review of rates and burden of harm of intravenous admixture drug preparation errors in healthcare settings.BMJ open · 2017Pooled it
- Parenteral morphine and oxycodone mixtures administered in specialised palliative and hospice care units: A retrospective medical record review.Palliative care and social practice · 2025Article
- Impact of a Bundle of Interventions on the Spectrum of Parenteral Drug Preparation Errors in a Neonatal and Pediatric Intensive Care Unit.Journal of clinical medicine · 2024Article
- Long-term stability of 10 mg/mL dobutamine injectable solutions in 5% dextrose and normal saline solution stored in polypropylene syringes and cyclic-oleofin-copolymer vials.European journal of hospital pharmacy : science and practice · 2023Article
- Prevalence and determinants of intravenous admixture preparation errors: A prospective observational study in a university hospital.International journal of clinical pharmacy · 2022Observational
- An Economic Analysis of Critical Care Nurse Resourcing Following the Uptake of Ready-to-Administer Noradrenaline for Hypotensive Shock in Adults in England.Advances in therapy · 2022Article
- Long-term stability of ready-to-use norepinephrine solution at 0.2 and 0.5 mg/mL.European journal of hospital pharmacy : science and practice · 2020Article
- Robotic Therapy: Cost, Accuracy, and Times. New Challenges in the Neonatal Intensive Care Unit.Frontiers in pharmacology · 2019Article
- Article
- Accuracy of intravenous and enteral preparations involving small volumes for paediatric use: a review.European journal of hospital pharmacy : science and practice · 2018Review
- Ready-to-use parenteral amiodarone: a feasibility study towards a long-term stable product formulation.European journal of hospital pharmacy : science and practice · 2017Article
- Infusion medication concentrations in UK's critical care areas: Are the Intensive Care Society's recommendations being used?Journal of the Intensive Care Society · 2017Article
- What's in that syringe? Standard drug concentrations in critical care.Journal of the Intensive Care Society · 2017Article
- Effect of intensive care environment on family and patient satisfaction: a before-after study.Intensive care medicine · 2013Article
- Random errors in insulin infusion concentrations.Intensive care medicine · 2012Article
- Year in review in Intensive Care Medicine 2011. II. Cardiovascular, infections, pneumonia and sepsis, critical care organization and outcome, education, ultrasonography, metabolism and coagulation.Intensive care medicine · 2012Review
- Medication errors in oral dosage form preparation for neonates: The importance of preparation technique.Journal of research in pharmacy practiceArticle
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the concentration conformity of infusion solutions manually prepared on intensive care units (ICU) with solutions from pharmacy-based, automated production.
methodsA prospective observational study conducted in a university hospital in Germany. Drug concentrations of 100 standardised infusion solutions manually prepared in the ICU and 100 matching solutions from automated production containing amiodarone, noradrenaline or hydrocortisone were measured by high-performance liquid chromatography analysis. Deviations from stated concentrations were calculated, and the quality of achieved concentration conformity of the two production methods was compared.
resultsActual concentrations of 53% of the manually prepared and 16% of the machine-made solutions deviated by >5% above or below the stated concentration. A deviation of >10% was measured in 22% of the manually prepared samples and in 5% of samples from automated production. Of the manually prepared solutions, 15% deviated by >15% above or below the intended concentration. The mean concentration of the manually prepared solutions was 97.2% (SD 12.7%, range 45-129%) and of the machine-made solutions was 101.1% (SD 4.3%, range 90-114%) of the target concentration (p < 0.01).
conclusionsIn this preliminary study, ward-based, manually prepared infusion solutions showed clinically relevant deviations in concentration conformity significantly more often than pharmacy-prepared, machine-made solutions. Centralised, automated preparation of standardised infusion solutions may be an effective means to reduce this type of medication error. Further confirmatory studies in larger settings and under conditions of routine automated production are required.
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