ArticleIntensive care medicine2011
Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
106 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Renal Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Pediatrics · 2022Pooled it
- The Japanese clinical practice guideline for acute kidney injury 2016.Clinical and experimental nephrology · 2018Guideline
- Association Between Fluid Balance and Outcomes in Critically Ill Children: A Systematic Review and Meta-analysis.JAMA pediatrics · 2018Pooled it
- Pattern of Fluid Overload and its Impact on Mortality Among Mechanically Ventilated Children: Secondary Analysis of the ReLiSCh Trial.Indian journal of pediatrics · 2025Trial
- Restricted versus Usual/Liberal Maintenance Fluid Strategy in Mechanically Ventilated Children: An Open-Label Randomized Trial (ReLiSCh Trial).Indian journal of pediatrics · 2025Trial
- Diuretics decrease fluid balance in patients on invasive mechanical ventilation: the randomized-controlled single blind, IRIHS study.Critical care (London, England) · 2021Trial
- Reconsidering boundaries: extracorporeal membrane oxygenation candidacy for neonates with congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2026Article
- Fluid accumulation and outcomes in children receiving continuous kidney replacement therapy: an appraisal of the WE-ROCK registry.Pediatric nephrology (Berlin, Germany) · 2026Article
- Fluid balance during PICU stay in children after cardiac surgery with cardiopulmonary bypass.European journal of pediatrics · 2026Article
- Continuous kidney replacement therapy with CARPEDIEMPediatric nephrology (Berlin, Germany) · 2026Article
- Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance.Critical care explorations · 2026Observational
- Acute kidney injury in extremely preterm infants: findings from an Australian single-centre retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Korean Society of Nephrology 2025 Evidence-Based Clinical Practice Guideline for Continuous Kidney Replacement Therapy.Electrolyte & blood pressure : E & BP · 2026Review
- Korean Society of Nephrology 2025 evidence-based clinical practice guideline for continuous kidney replacement therapy.Kidney research and clinical practice · 2026Article
- Reducing NICU ventilator days by preventing fluid overload with the CAN-U-P-LOTS standardized bundle.Pediatric research · 2026Article
- Article
- Barriers and opportunities to improve fluid balance recognition and reduction: a qualitative study.Frontiers in pediatrics · 2026Article
- Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance.medRxiv : the preprint server for health sciences · 2025Article
- Risk factors for adverse short-term and long-term outcomes in children with severe acute kidney injury requiring continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2025Article
- Advancements in research on fluid overload in preterm infants-a narrative review.Frontiers in pediatrics · 2025Review
46 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
purposeIn pediatric intensive care unit (PICU) patients, fluid overload (FO) at initiation of continuous renal replacement therapy (CRRT) has been reported to be an independent risk factor for mortality. Previous studies have calculated FO based on daily fluid balance during ICU admission, which is labor intensive and error prone. We hypothesized that a weight-based definition of FO at CRRT initiation would correlate with the fluid balance method and prove predictive of outcome.
methodsThis is a retrospective single-center review of PICU patients requiring CRRT from July 2006 through February 2010 (n = 113). We compared the degree of FO at CRRT initiation using the standard fluid balance method versus methods based on patient weight changes assessed by both univariate and multivariate analyses.
resultsThe degree of fluid overload at CRRT initiation was significantly greater in nonsurvivors, irrespective of which method was used. The univariate odds ratio for PICU mortality per 1% increase in FO was 1.056 [95% confidence interval (CI) 1.025, 1.087] by the fluid balance method, 1.044 (95% CI 1.019, 1.069) by the weight-based method using PICU admission weight, and 1.045 (95% CI 1.022, 1.07) by the weight-based method using hospital admission weight. On multivariate analyses, all three methods approached significance in predicting PICU survival.
conclusionsOur findings suggest that weight-based definitions of FO are useful in defining FO at CRRT initiation and are associated with increased mortality in a broad PICU patient population. This study provides evidence for a more practical weight-based definition of FO that can be used at the bedside.
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