ArticlePloS one2011
A preliminary study of genetic factors that influence susceptibility to bovine tuberculosis in the British cattle herd.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Data-intensive immune network modelling for One Health.Briefings in bioinformatics · 2026Review
- Integrative genomics sheds light on the immunogenetics of tuberculosis in cattle.Communications biology · 2025Article
- Exploring the genetic factors behind the discrepancy in resistance to bovine tuberculosis between African zebu cattle and European taurine cattle.Scientific reports · 2024Article
- Divergent proinflammatory immune responses associated with the differential susceptibility of cattle breeds to tuberculosis.Frontiers in immunology · 2023Article
- Genetic Diversity of Cameroon Cattle and a Putative Genomic Map for Resistance to Bovine Tuberculosis.Frontiers in genetics · 2020Article
- An analysis of effects of heterozygosity in dairy cattle for bovine tuberculosis resistance.Animal genetics · 2018Article
- Prevalence and risk factors of mycobacterial infections in farm and trade cattle in southwestern Nigeria.Tropical animal health and production · 2018Article
- Association ofFrontiers in veterinary science · 2018Article
- Animal Models for Tuberculosis in Translational and Precision Medicine.Frontiers in microbiology · 2017Review
- A review of risk factors for bovine tuberculosis infection in cattle in the UK and Ireland.Epidemiology and infection · 2016Review
- Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis.Heredity · 2014Article
- Article
- Asymptomatic cattle naturally infected with Mycobacterium bovis present exacerbated tissue pathology and bacterial dissemination.PloS one · 2013Article
- Field-isolated genotypes of Mycobacterium bovis vary in virulence and influence case pathology but do not affect outbreak size.PloS one · 2013Article
- Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.PloS one · 2013Article
- Genetic predisposition to pass the standard SICCT test for bovine tuberculosis in British cattle.PloS one · 2013Article
- The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia.Comparative immunology, microbiology and infectious diseases · 2012Review
- A genome wide association scan of bovine tuberculosis susceptibility in Holstein-Friesian dairy cattle.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Associations between specific host genes and susceptibility to Mycobacterial infections such as tuberculosis have been reported in several species. Bovine tuberculosis (bTB) impacts greatly the UK cattle industry, yet genetic predispositions have yet to be identified. We therefore used a candidate gene approach to study 384 cattle of which 160 had reacted positively to an antigenic skin test ('reactors'). Our approach was unusual in that it used microsatellite markers, embraced high breed diversity and focused particularly on detecting genes showing heterozygote advantage, a mode of action often overlooked in SNP-based studies. A panel of neutral markers was used to control for population substructure and using a general linear model-based approach we were also able to control for age. We found that substructure was surprisingly weak and identified two genomic regions that were strongly associated with reactor status, identified by markers INRA111 and BMS2753. In general the strength of association detected tended to vary depending on whether age was included in the model. At INRA111 a single genotype appears strongly protective with an overall odds ratio of 2.2, the effect being consistent across nine diverse breeds. Our results suggest that breeding strategies could be devised that would appreciably increase genetic resistance of cattle to bTB (strictly, reduce the frequency of incidence of reactors) with implications for the current debate concerning badger-culling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.