ArticlePloS one2011
The extraordinarily complex but highly structured organization of intestinal mucus-gel unveiled in multicolor images.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Intestinal Fucosylation: A Key Regulatory Hub in Homeostasis and Disease Pathogenesis.Biomolecules · 2026Review
- A preliminary study of HMGB1 defense in Crohn's disease.bioRxiv : the preprint server for biology · 2026Article
- Industrialized human gut microbiota increases CD8+ T cells and mucus thickness in humanized mouse gut.Gut microbes · 2023Article
- Deletion of Constitutive Androstane Receptor Led to Intestinal Alterations and Increased Imidacloprid in Murine Liver.Journal of the Endocrine Society · 2022Article
- A porous cervical mucus plug leads to preterm birth induced by experimental vaginal infection in mice.iScience · 2022Article
- The Fast Track for Intestinal Tumor Cell Differentiation and In Vitro Intestinal Models by Inorganic Topographic Surfaces.Pharmaceutics · 2022Article
- Article
- Impact and consequences of intensive chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: the role of mucosal strengthening.Gut microbes · 2020Article
- Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.Histochemistry and cell biology · 2019Article
- Therapeutic effect of gold nanoparticles on DSS-induced ulcerative colitis in mice with reference to interleukin-17 expression.Scientific reports · 2019Article
- Mechanical shear controls bacterial penetration in mucus.Scientific reports · 2019Article
- Using 3D gastrointestinal tract in vitro models with microfold cells and mucus secreting ability to assess the hazard of copper oxide nanomaterials.Journal of nanobiotechnology · 2019Article
- The Gut Microbiome: Connecting Spatial Organization to Function.Cell host & microbe · 2017Review
- Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria.Nature communications · 2016Article
- Review
- Distinct but Spatially Overlapping Intestinal Niches for Vancomycin-Resistant Enterococcus faecium and Carbapenem-Resistant Klebsiella pneumoniae.PLoS pathogens · 2015Article
- Carbachol-induced colonic mucus formation requires transport via NKCC1, K⁺ channels and CFTR.Pflugers Archiv : European journal of physiology · 2015Article
- Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier.Scientific reports · 2015Article
- Endotoxin-induced changes in phospholipid dynamics of the stomach.The Journal of surgical research · 2013Article
- Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways.Mucosal immunology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mucus that coats the gastrointestinal tract of all mammals is a dynamic and sticky gel layer and represents the first protective barrier between the host and the hostile environment. There is, however, a lack of detailed knowledge about the mucus gel organization because of the high water content and the complexity of MUC2, the main gel-forming molecule in the intestine. Histological staining and a multilabel immunofluorescence method were used to examine mucus blankets and Muc2 in mouse colon and ileum samples fixed in Carnoy's solution, unveiling an extraordinarily complex but highly structured mucus gel organization. The inner firmly adherent mucus blanket consists of alternating layers. The thicker outer loosely adherent mucus blanket in the colon is made of alternating laminated layers and loose curl-like structures. The layers consist of Muc2 molecules with different fucosylation states and glycoforms remain unmixed in the mucus. Importantly, distinct goblet cell subpopulations throughout the ileum along the crypt-to-villus axis with an alternation of goblet cells secreting fucosylated and non-fucosylated Muc2 are observed. A better understanding of the mucus structure should contribute to improve the efficiency of DNA and drug delivery and will allow for a better understanding and treatment of inflammatory and infectious intestinal diseases.
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Registered trials
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