ArticlePloS one2011
Diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 92 citations in OpenAlex.
- Unveiling Diet Preferences and Their Nutritional Drivers Through Metabarcoding: The Case of Alpine Marmot (Ecology and evolution · 2026Article
- Mechanisms of energy metabolism reprogramming and homeostasis maintenance in overwintering hibernating animals.Frontiers in veterinary science · 2026Review
- Frequency-modulated timer regulates torpor-arousal cycles during hibernation in distinct small mammalian hibernators.Npj biological timing and sleep · 2024Article
- Pre-hibernation diet alters skeletal muscle relaxation kinetics, but not force development in torpid arctic ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Summer fades, deer change: Photoperiodic control of cellular seasonal acclimatization of skeletal muscle.iScience · 2024Article
- The Influence of Photoperiod, Intake of Polyunsaturated Fatty Acids, and Food Availability on Seasonal Acclimatization in Red Deer (Animals : an open access journal from MDPI · 2023Article
- Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation.PloS one · 2023Article
- Energy expenditure and body composition in a hibernator, the alpine marmot.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Translating PUFA omega 6:3 ratios from wild to captive hibernators (Urocitellus parryii) enhances sex-dependent mass-gain without increasing physiological stress indicators.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Article
- Molecular Liver Fingerprint Reflects the Seasonal Physiology of the Grey Mouse Lemur (International journal of molecular sciences · 2022Article
- Article
- Hypothesis and Theory: A Two-Process Model of Torpor-Arousal Regulation in Hibernators.Frontiers in physiology · 2022Article
- Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol.Communications biology · 2021Article
- Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel.Scientific reports · 2021Article
- Specific shifts in the endocannabinoid system in hibernating brown bears.Frontiers in zoology · 2020Article
- Regulation of Peroxisome Proliferator-Activated Receptor Pathway During Torpor in the Garden Dormouse,Frontiers in physiology · 2020Article
- Fatty acid profiles of the European migratory common noctule bat (Nyctalus noctula).Die Naturwissenschaften · 2019Article
- Article
- Lipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear.Frontiers in physiology · 2019Article
- Seasonal changes in eicosanoid metabolism in the brown bear.Die Naturwissenschaften · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyunsaturated fatty acids (PUFA) have a multitude of health effects. Their incorporation into membrane phospholipids (PL) is generally believed to depend directly on dietary influx. PL influence transmembrane protein activity and thus can compensate temperature effects; e.g. PL n-6 PUFA are thought to stabilize heart function at low body temperature (T(b)), whereas long chain (>C18) n-3 PUFA may boost oxidative capacity. We found substantial remodeling of membranes in free-living alpine marmots which was largely independent of direct dietary supply. Organ PL n-6 PUFA and n-6 to n-3 ratios were highest at onset and end of hibernation after rapid increases during a brief transitional period prior to hibernation. In contrast, longer chain PL n-3 PUFA content was low at end of summer but maximal at end of hibernation. After termination of hibernation in spring, these changes in PL composition were rapidly reversed. Our results demonstrate selective trafficking of PUFA within the body, probably governed by a circannual endogenous rhythm, as hibernating marmots were in winter burrows isolated for seven months from food and external cues signaling the approaching spring. High concentrations of PL n-6 PUFA throughout hibernation are in line with their hypothesized function of boosting SERCA 2a activity at low T(b). Furthermore, we found increasing rate of rewarming from torpor during winter indicating increasing oxidative capacity that could be explained by the accumulation of long-chain PL n-3 PUFA. It may serve to minimize the time necessary for rewarming despite the increasing temperature range to be covered, because rewarming is a period of highest metabolic rate and hence production of reactive oxygen species. Considering the importance of PUFA for health our results may have important biomedical implications, as seasonal changes of T(b) and associated remodeling of membranes are not restricted to hibernators but presumably common among endothermic organisms.
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