ArticlePloS one2011
Early growth response gene-2 (Egr-2) regulates the development of B and T cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβImmunology · 2026Article
- Enhancing the potency of CAR-T cells against solid tumors through transcription factor engineering.JCI insight · 2025Review
- Manual Therapy Improves Fibromyalgia Symptoms by DownregulatingInternational journal of molecular sciences · 2024Observational
- Article
- EGR2 Deletion Suppresses Anti-DsDNA Autoantibody and IL-17 Production in Autoimmune-Prone B6/lpr Mice: A Differential Immune Regulatory Role of EGR2 in B6/lpr Versus Normal B6 Mice.Frontiers in immunology · 2022Article
- Transcriptional Regulation of Early T-Lymphocyte Development in Thymus.Frontiers in immunology · 2022Review
- Early Growth Response Gene Upregulation in Epstein-Barr Virus (EBV)-Associated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).Biomolecules · 2020Review
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells.Genes & development · 2018Article
- Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.The Journal of experimental medicine · 2017Article
- Nab2 maintains thymus cellularity with aging and stress.Molecular immunology · 2017Article
- Early growth response 2 and Egr3 are unique regulators in immune system.Central-European journal of immunology · 2017Review
- Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cloning and characterizing of the murine IRF-3 gene promoter region.Immunologic research · 2016Article
- Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis.Oncotarget · 2016Article
- TLR9 ligation in pancreatic stellate cells promotes tumorigenesis.The Journal of experimental medicine · 2015Article
- Direct Conversion of Cord Blood CD34+ Cells Into Neural Stem Cells by OCT4.Stem cells translational medicine · 2015Article
- T-cell activation and early gene response in dogs.PloS one · 2015Article
- EGR2 is critical for peripheral naïve T-cell differentiation and the T-cell response to influenza.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundUnderstanding of how transcription factors are involved in lymphocyte development still remains a challenge. It has been shown that Egr-2 deficiency results in impaired NKT cell development and defective positive selection of T cells. Here we investigated the development of T, B and NKT cells in Egr-2 transgenic mice and the roles in the regulation of distinct stages of B and T cell development. METHODS AND
findingsThe expression of Egr1, 2 and 3 were analysed at different stages of T and B cell development by RT-PCT and results showed that the expression was strictly regulated at different stages. Forced expression of Egr-2 in CD2(+) lymphocytes resulted in a severe reduction of CD4(+)CD8(+) (DP) cells in thymus and pro-B cells in bone marrow, which was associated with reduced expression of Notch1 in ISP thymocytes and Pax5 in pro-B cells, suggesting that retraction of Egr-2 at the ISP and pro-B cell stages is important for the activation of lineage differentiation programs. In contrast to reduction of DP and pro-B cells, Egr-2 enhanced the maturation of DP cells into single positive (SP) T and NKT cells in thymus, and immature B cells into mature B cells in bone marrow.
conclusionsOur results demonstrate that Egr-2 expressed in restricted stages of lymphocyte development plays a dynamic, but similar role for the development of T, NKT and B cells.
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