ArticlePloS one2011
Role of germination in murine airway CD8+ T-cell responses to Aspergillus conidia.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Aspergillus fumigatus viability drives allergic responses to inhaled conidia.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Article
- Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis.Journal of visualized experiments : JoVE · 2018Article
- Preparations for Invasion: Modulation of Host Lung Immunity During PulmonaryFrontiers in immunology · 2018Review
- Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary Aspergillosis.Scientific reports · 2017Article
- Caspofungin Increases Fungal Chitin and Eosinophil and γδ T Cell-Dependent Pathology in Invasive Aspergillosis.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Methods of Controlling Invasive Fungal Infections Using CD8Frontiers in immunology · 2017Review
- Rodent Models of Invasive Aspergillosis due toFrontiers in microbiology · 2017Review
- Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- Generation and Characterization of Indoor Fungal Aerosols for Inhalation Studies.Applied and environmental microbiology · 2016Article
- Occupational exposure levels of bioaerosol components are associated with serum levels of the acute phase protein Serum Amyloid A in greenhouse workers.Environmental health : a global access science source · 2016Article
- Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection.Infection and immunity · 2014Article
- A murine inhalation model to characterize pulmonary exposure to dry Aspergillus fumigatus conidia.PloS one · 2014Article
- Isolate-dependent growth, virulence, and cell wall composition in the human pathogen Aspergillus fumigatus.PloS one · 2014Article
- CD8(+) T cells implicated in the pathogenesis of allergic fungal rhinosinusitis.Allergy & rhinology (Providence, R.I.) · 2014Article
- The immune interplay between the host and the pathogen in Aspergillus fumigatus lung infection.BioMed research international · 2013Review
- T cell-mediated host immune defenses in the lung.Annual review of immunology · 2013Review
- Microcolony imaging of Aspergillus fumigatus treated with echinocandins reveals both fungistatic and fungicidal activities.PloS one · 2012Article
- Lung eosinophil recruitment in response to Aspergillus fumigatus is correlated with fungal cell wall composition and requires γδ T cells.Microbes and infectionArticle
- Pulmonary immune responses to Aspergillus fumigatus in an immunocompetent mouse model of repeated exposures.Journal of immunotoxicologyArticle
- Cultivation and aerosolization ofInhalation toxicologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Pulmonary exposure to Aspergillus fumigatus has been associated with morbidity and mortality, particularly in immunocompromised individuals. A. fumigatus conidia produce β-glucan, proteases, and other immunostimulatory factors upon germination. Murine models have shown that the ability of A. fumigatus to germinate at physiological temperature may be an important factor that facilitates invasive disease. We observed a significant increase in IFN-γ-producing CD8(+) T cells in bronchoalveolar lavage fluid (BALF) of immunocompetent mice that repeatedly aspirated A. fumigatus conidia in contrast to mice challenged with A. versicolor, a species that is not typically associated with invasive, disseminated disease. Analysis of tissue sections indicated the presence of germinating spores in the lungs of mice challenged with A. fumigatus, but not A. versicolor. Airway IFN-γ(+)CD8(+) T-cells were decreased and lung germination was eliminated in mice that aspirated A. fumigatus conidia that were formaldehyde-fixed or heat-inactivated. Furthermore, A. fumigatus particles exhibited greater persistence in the lungs of recipient mice when compared to non-viable A. fumigatus or A. versicolor, and this correlated with increased maintenance of airway memory-phenotype CD8(+) T cells. Therefore, murine airway CD8(+) T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. These results provide further evidence of induction of immune responses to fungi based on their ability to invade host tissue.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.