ArticlePloS one2011
Evidence for reductive genome evolution and lateral acquisition of virulence functions in two Corynebacterium pseudotuberculosis strains.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 125 citations in OpenAlex.
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- Pilot study on the distribution of caseous lymphadenitis in Korean native goats and the relationship between sex and age in disease occurrence.Frontiers in veterinary science · 2023Article
- Molecular Characterization ofVeterinary sciences · 2021Article
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- Reconstructing the Phylogeny of Corynebacteriales while Accounting for Horizontal Gene Transfer.Genome biology and evolution · 2020Article
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- Binding studies of a putative C. pseudotuberculosis target protein from Vitamin BScientific reports · 2019Article
- NMR insights on nano silver post-surgical treatment of superficial caseous lymphadenitis in small ruminants.RSC advances · 2018Article
- Identification of membrane-associated proteins with pathogenic potential expressed by Corynebacterium pseudotuberculosis grown in animal serum.BMC research notes · 2018Article
- Rapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosis.PloS one · 2018Article
- Identification of new Corynebacterium pseudotuberculosis antigens by immunoscreening of gene expression library.BMC microbiology · 2017Article
- Label-free quantitative proteomics of Corynebacterium pseudotuberculosis isolates reveals differences between Biovars ovis and equi strains.BMC genomics · 2017Article
- A shift in the virulence potential of Corynebacterium pseudotuberculosis biovar ovis after passage in a murine host demonstrated through comparative proteomics.BMC microbiology · 2017Article
- Insight of GenusFrontiers in microbiology · 2017Review
- Multilocus Sequencing ofBioMed research international · 2017Article
- Comparative genomic analysis between Corynebacterium pseudotuberculosis strains isolated from buffalo.PloS one · 2017Article
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Authors and funding
59 authors at 15 institutions in 3 countries.
Funding
Abstract
backgroundCorynebacterium pseudotuberculosis, a gram-positive, facultative intracellular pathogen, is the etiologic agent of the disease known as caseous lymphadenitis (CL). CL mainly affects small ruminants, such as goats and sheep; it also causes infections in humans, though rarely. This species is distributed worldwide, but it has the most serious economic impact in Oceania, Africa and South America. Although C. pseudotuberculosis causes major health and productivity problems for livestock, little is known about the molecular basis of its pathogenicity. METHODOLOGY AND
findingsWe characterized two C. pseudotuberculosis genomes (Cp1002, isolated from goats; and CpC231, isolated from sheep). Analysis of the predicted genomes showed high similarity in genomic architecture, gene content and genetic order. When C. pseudotuberculosis was compared with other Corynebacterium species, it became evident that this pathogenic species has lost numerous genes, resulting in one of the smallest genomes in the genus. Other differences that could be part of the adaptation to pathogenicity include a lower GC content, of about 52%, and a reduced gene repertoire. The C. pseudotuberculosis genome also includes seven putative pathogenicity islands, which contain several classical virulence factors, including genes for fimbrial subunits, adhesion factors, iron uptake and secreted toxins. Additionally, all of the virulence factors in the islands have characteristics that indicate horizontal transfer.
conclusionsThese particular genome characteristics of C. pseudotuberculosis, as well as its acquired virulence factors in pathogenicity islands, provide evidence of its lifestyle and of the pathogenicity pathways used by this pathogen in the infection process. All genomes cited in this study are available in the NCBI Genbank database (http://www.ncbi.nlm.nih.gov/genbank/) under accession numbers CP001809 and CP001829.
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