ArticlePloS one2011
Comparative pathogenesis of three human and zoonotic SARS-CoV strains in cynomolgus macaques.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control.Signal transduction and targeted therapy · 2024Review
- Animal models for studying coronavirus infections and developing antiviral agents and vaccines.Antiviral research · 2022Review
- Immune interventions in COVID-19: a matter of time?Mucosal immunology · 2022Review
- A Case Study to Dissect Immunity to SARS-CoV-2 in a Neonate Nonhuman Primate Model.Frontiers in immunology · 2022Article
- Susceptibility of white-tailed deer (Journal of virology · 2021Article
- Animal and translational models of SARS-CoV-2 infection and COVID-19.Mucosal immunology · 2020Review
- Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19.ERJ open research · 2020Review
- Review
- Mobilizing animal models against a pandemic.Lab animal · 2020Article
- Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.Science (New York, N.Y.) · 2020Article
- Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells.Frontiers in immunology · 2020Article
- Broad-spectrum coronavirus antiviral drug discovery.Expert opinion on drug discovery · 2019Review
- Host gene expression profiles in ferrets infected with genetically distinct henipavirus strains.PLoS neglected tropical diseases · 2018Article
- Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus.Virology · 2015Review
- The pathology and pathogenesis of experimental severe acute respiratory syndrome and influenza in animal models.Journal of comparative pathology · 2014Review
- A decade after SARS: strategies for controlling emerging coronaviruses.Nature reviews. Microbiology · 2013Review
- Bugs in the system.Immunological reviews · 2013Review
- Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
The severe acute respiratory syndrome (SARS) epidemic was characterized by increased pathogenicity in the elderly due to an early exacerbated innate host response. SARS-CoV is a zoonotic pathogen that entered the human population through an intermediate host like the palm civet. To prevent future introductions of zoonotic SARS-CoV strains and subsequent transmission into the human population, heterologous disease models are needed to test the efficacy of vaccines and therapeutics against both late human and zoonotic isolates. Here we show that both human and zoonotic SARS-CoV strains can infect cynomolgus macaques and resulted in radiological as well as histopathological changes similar to those seen in mild human cases. Viral replication was higher in animals infected with a late human phase isolate compared to a zoonotic isolate. While there were significant differences in the number of host genes differentially regulated during the host responses between the three SARS-CoV strains, the top pathways and functions were similar and only apparent early during infection with the majority of genes associated with interferon signaling pathways. This study characterizes critical disease models in the evaluation and licensure of therapeutic strategies against SARS-CoV for human use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.