ArticlePloS one2011
Host specific diversity in Lactobacillus johnsonii as evidenced by a major chromosomal inversion and phage resistance mechanisms.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Strain-resolved biology ofFrontiers in veterinary science · 2026Review
- Article
- Characterization of Probiotic Properties and Whole-Genome Analysis ofMicroorganisms · 2024Article
- Functional and genomic characterization of a novel probiotic Lactobacillus johnsonii KD1 against shrimp WSSV infection.Scientific reports · 2023Article
- Review
- Phage resistance formation and fitness costs of hypervirulentFrontiers in microbiology · 2023Article
- Comparative genomics of Lactobacillaceae from the gut of honey bees, Apis mellifera, from the Eastern United States.G3 (Bethesda, Md.) · 2022Article
- Identification of Genes Required for Glucan Exopolysaccharide Production in Lactobacillus johnsonii Suggests a Novel Biosynthesis Mechanism.Applied and environmental microbiology · 2020Article
- A Frameshift Mutation inMicroorganisms · 2020Article
- Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance.mSystems · 2020Article
- Complete Genome Sequencing and Comparative Genome Characterization ofFrontiers in genetics · 2019Article
- New Insights Into Cinnamoyl Esterase Activity ofFrontiers in microbiology · 2019Article
- Comparative Genomics Reveals the Diversity of Restriction-Modification Systems and DNA Methylation Sites in Listeria monocytogenes.Applied and environmental microbiology · 2017Article
- Gene expression of lactobacilli in murine forestomach biofilms.Microbial biotechnology · 2014Article
- The evolutionary divergence of Shiga toxin-producing Escherichia coli is reflected in clustered regularly interspaced short palindromic repeat (CRISPR) spacer composition.Applied and environmental microbiology · 2013Article
- Article
- Genome sequence of Lactobacillus johnsonii PF01, isolated from piglet feces.Journal of bacteriology · 2011Article
- Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again.Microbial cell factories · 2011Review
Corrections and comments
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Genetic diversity and genomic rearrangements are a driving force in bacterial evolution and niche adaptation. We sequenced and annotated the genome of Lactobacillus johnsonii DPC6026, a strain isolated from the porcine intestinal tract. Although the genome of DPC6026 is similar in size (1.97 mbp) and GC content (34.8%) to the sequenced human isolate L. johnsonii NCC 533, a large symmetrical inversion of approximately 750 kb differentiated the two strains. Comparative analysis among 12 other strains of L. johnsonii including 8 porcine, 3 human and 1 poultry isolate indicated that the genome architecture found in DPC6026 is more common within the species than that of NCC 533. Furthermore a number of unique features were annotated in DPC6026, some of which are likely to have been acquired by horizontal gene transfer (HGT) and contribute to protection against phage infection. A putative type III restriction-modification system was identified, as were novel Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) elements. Interestingly, these particular elements are not widely distributed among L. johnsonii strains. Taken together these data suggest intra-species genomic rearrangements and significant genetic diversity within the L. johnsonii species and indicate towards a host-specific divergence of L. johnsonii strains with respect to genome inversion and phage exposure.
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