ArticlePloS one2011
Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.PloS one · 2018Article
- March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation.Journal of immunology research · 2018Article
- Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer.BMC medical genetics · 2017Article
- Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.The Journal of experimental medicine · 2016Article
- Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses.The Journal of experimental medicine · 2016Article
- Molecular mechanism and cellular function of MHCII ubiquitination.Immunological reviews · 2015Review
- MHC class II antigen presentation by dendritic cells regulated through endosomal sorting.Cold Spring Harbor perspectives in biology · 2013Review
- Beyond the classical: influenza virus and the elucidation of alternative MHC class II-restricted antigen processing pathways.Immunologic research · 2011Review
- Towards a systems understanding of MHC class I and MHC class II antigen presentation.Nature reviews. Immunology · 2011Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controlled localization of class II MHC molecules is essential for proper class II MHC-restricted antigen presentation and the subsequent initiation of an adaptive immune response. Ubiquitination of class II MHC molecules on cytosolic lysine (K225) of the β-chain has been shown to affect localization of the complex. We generated mice in which the endogenous β-chain locus is replaced with a GFP tagged mutant version that lacks the cytosolic lysine residue (I-A-β-K225R-EGFP). These mice have elevated levels of class II MHC as compared to I-A-β-EGFP mice, and immature bone marrow-derived dendritic cells show redistribution of class II MHC to the cell surface. Nonetheless, in these same cells efficiency of antigen presentation is unaffected in I-A-β-K225R-EGFP mice, as assayed for presentation of ovalbumin to appropriately specific T cells. The I-A-β-K225R-EGFP animals have normal CD4 T cell populations and are capable of generating antigen-specific antibody in response to model antigens and viral infection. We therefore conclude that in our experimental system modulation of trafficking by ubiquitination of residue K225 of the β-chain is not essential for the function of class II MHC products in antigen presentation or antibody production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.