ArticlePLoS computational biology2011
Linking microscopic spatial patterns of tissue destruction in emphysema to macroscopic decline in stiffness using a 3D computational model.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Advances in human organs-on-chips and applications for drug screening and personalized medicine.Fundamental research · 2025Review
- A 3D Epithelial-Mesenchymal Co-Culture Model of the Airway Wall Using Native Lung Extracellular Matrix.Bioengineering (Basel, Switzerland) · 2024Article
- Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling.JCI insight · 2024Article
- Changes in Lung Volumes with Spirometric Disease Progression in COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023Article
- Predicting alveolar ventilation heterogeneity in pulmonary fibrosis using a non-uniform polyhedral spring network model.Frontiers in network physiology · 2023Article
- Impact of the Amyotrophic Lateral Sclerosis Disease on the Biomechanical Properties and Oxidative Stress Metabolism of the Lung Tissue Correlated With the Human Mutant SOD1Frontiers in bioengineering and biotechnology · 2022Article
- Tissue-specific parameters for the design of ECM-mimetic biomaterials.Acta biomaterialia · 2021Review
- Percolation of collagen stress in a random network model of the alveolar wall.Scientific reports · 2021Article
- Microphysiological Systems: Design, Fabrication, and Applications.ACS biomaterials science & engineering · 2020Article
- An Analytical Model for Estimating Alveolar Wall Elastic Moduli From Lung Tissue Uniaxial Stress-Strain Curves.Frontiers in physiology · 2020Article
- CT Imaging-Based Low-Attenuation Super Clusters in Three Dimensions and the Progression of Emphysema.Chest · 2019Observational
- Topographic distribution of idiopathic pulmonary fibrosis: a hybrid physics- and agent-based model.Physiological measurement · 2018Article
- Coupled Immunological and Biomechanical Model of Emphysema Progression.Frontiers in physiology · 2018Article
- Biophysical Regulation of Cell Behavior-Cross Talk between Substrate Stiffness and Nanotopography.Engineering (Beijing, China) · 2017Article
- Predicting Structure-Function Relations and Survival following Surgical and Bronchoscopic Lung Volume Reduction Treatment of Emphysema.PLoS computational biology · 2017Article
- The extracellular matrix - the under-recognized element in lung disease?The Journal of pathology · 2016Review
- Mechanical Forces Accelerate Collagen Digestion by Bacterial Collagenase in Lung Tissue Strips.Frontiers in physiology · 2016Article
- Entropy Production and the Pressure-Volume Curve of the Lung.Frontiers in physiology · 2016Article
- Lung extracellular matrix and fibroblast function.Annals of the American Thoracic Society · 2015Review
- Scale dependence of structure-function relationship in the emphysematous mouse lung.Frontiers in physiology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pulmonary emphysema is a connective tissue disease characterized by the progressive destruction of alveolar walls leading to airspace enlargement and decreased elastic recoil of the lung. However, the relationship between microscopic tissue structure and decline in stiffness of the lung is not well understood. In this study, we developed a 3D computational model of lung tissue in which a pre-strained cuboidal block of tissue was represented by a tessellation of space filling polyhedra, with each polyhedral unit-cell representing an alveolus. Destruction of alveolar walls was mimicked by eliminating faces that separate two polyhedral either randomly or in a spatially correlated manner, in which the highest force bearing walls were removed at each step. Simulations were carried out to establish a link between the geometries that emerged and the rate of decline in bulk modulus of the tissue block. The spatially correlated process set up by the force-based destruction lead to a significantly faster rate of decline in bulk modulus accompanied by highly heterogeneous structures than the random destruction pattern. Using the Karhunen-Loève transformation, an estimator of the change in bulk modulus from the first four moments of airspace cell volumes was setup. Simulations were then obtained for tissue destruction with different idealized alveolar geometry, levels of pre-strain, linear and nonlinear elasticity assumptions for alveolar walls and also mixed destruction patterns where both random and force-based destruction occurs simultaneously. In all these cases, the change in bulk modulus from cell volumes was accurately estimated. We conclude that microscopic structural changes in emphysema and the associated decline in tissue stiffness are linked by the spatial pattern of the destruction process.
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