ArticleMacromolecules2010
Drug-loaded, bivalent-bottle-brush polymers by graft-through ROMP.
Article in Macromolecules, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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Who cites it
65 citing papers in PubMed, 333 citations in OpenAlex.
- Generalizable Strategies for the Synthesis of Cereblon-Recruiting PROTAC Prodrugs.Angewandte Chemie (International ed. in English) · 2026Article
- Hydrolytically Degradable Polyethylene Glycol Bottlebrush Polymers Address the Stability-Clearance Trade-Off for Drug Delivery.Polymer science & technology (Washington, D.C.) · 2026Article
- Stretching decelerates ring-opening metathesis at cis-olefins in stressed molecular bows.Nature communications · 2026Article
- Recyclable Graft Polymer Enabled by RAFT Step-Growth Polymerization and Deconstruction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Polypept(o)ide Based Biodegradable Cylindrical Polymer Brushes: Controlling Size, Shape, Surface Functionality, and Stability.ACS applied materials & interfaces · 2025Article
- Entropy Drives the Predictive Discovery of an Optimal Cleavable Comonomer for ROMP.ACS central science · 2025Article
- Branched Polymer Architecture for Modulating Interactions in Material-Bio Interface.Tissue engineering and regenerative medicine · 2025Review
- Molecular Structure of Foldable Bottlebrush Polymers in Melts.Macromolecules · 2025Article
- Article
- Hydrazine-Catalysed Ring-Opening Metathesis Polymerization Of Cyclobutenes.Angewandte Chemie (International ed. in English) · 2024Article
- Stimuli-sensitive polymer prodrug nanocarriers by reversible-deactivation radical polymerization.Chemical Society reviews · 2024Review
- Bottlebrush Networks: A Primer for Advanced Architectures.Angewandte Chemie (International ed. in English) · 2024Review
- Caspase-3-Responsive, Fluorogenic Bivalent Bottlebrush Polymers.ACS macro letters · 2024Article
- Bottlebrush Elastomers with Crystallizable Side Chains: Monolayer-like Structure of Backbones Segregated in Intercrystalline Regions.Polymers · 2024Article
- Novel epoxy-terminated macromonomers and their polymerization for synthesis of bottle-brush type amphiphilic block copolymers.RSC advances · 2023Article
- Synthesis of Bottlebrush Polymers byJournal of the American Chemical Society · 2023Article
- Sequestration of Ruthenium Residues via Efficient Fluorous-enyne Termination.Polymer chemistry · 2023Article
- Polymer architecture effect on rheology and segmental dynamics in poly (methyl methacrylate)-silica nanocomposite melts.Turkish journal of chemistry · 2023Article
- Review
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Graft-through ring-opening metathesis polymerization (ROMP) using ruthenium N-heterocyclic carbene catalysts has enabled the synthesis of bottle-brush polymers with unprecedented ease and control. Here we report the first bivalent-brush polymers; these materials were prepared by graft-through ROMP of drug-loaded polyethylene-glycol (PEG) based macromonomers (MMs). Anticancer drugs doxorubicin (DOX) and camptothecin (CT) were attached to a norbornene-alkyne-PEG MM via a photocleavable linker. ROMP of either or both drug-loaded MMs generated brush homo- and co-polymers with low polydispersities and defined molecular weights. Release of free DOX and CT from these materials was initiated by exposure to 365 nm light. All of the CT and DOX polymers were at least 10-fold more toxic to human cancer cells after photoinitiated drug release while a copolymer carrying both CT and DOX displayed 30-fold increased toxicity upon irradiation. Graft-through ROMP of drug-loaded macromonomers provides a general method for the systematic study of structure-function relationships for stimuli-responsive polymers in biological systems.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.