ArticleJournal of Korean medical science2011
Apolipoprotein B is highly associated with the risk of coronary heart disease as estimated by the Framingham risk score in healthy Korean men.
Article in Journal of Korean medical science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Statins in Healthy Adults: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Moving Beyond LDL-C and Non-HDL-C: Apolipoprotein B as the Stronger Lipid-Related Predictor of Coronary Artery Disease in Statin-Treated Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Exploring Utilization and Establishing Reference Intervals for the Apolipoprotein B Test in the Korean Population.Diagnostics (Basel, Switzerland) · 2023Article
- Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage.Annals of neurology · 2020Article
- Impact of depression on change in coronary heart disease risk status: the Korean Genome and Epidemiology Study (KoGES).Therapeutics and clinical risk management · 2018Article
- The influence of ApoE genotype on the lipid profile and lipoproteins during normal pregnancy in a Southern African population.African health sciences · 2016Article
- LDL-C, NON-HDL-C and APO-B for cardiovascular risk assessment: Looking for the ideal marker.Indian heart journalReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to examine the association between serum apolipoprotein B (apoB) and the risk of coronary heart disease (CHD) using Framingham risk score (FRS) in healthy Korean men. A total of 13,523 men without medication history of diabetes and hypertension were enrolled in this study. The FRS is based on six coronary risk factors. FRS ≥ 10% was defined as more-than-a-moderate risk group and FRS ≥ 20% as high risk group, respectively. The logistic regression analyses were conducted. When quartile 1 (Q1) set as a reference, in unadjusted analyses, the Q2, Q3, Q4 of apoB level had increased odds ratio (OR) for the risk of CHD in both more-than-a-moderate risk and high risk group, respectively. After adjusting for confounding variables, multivariable-adjusted logistic regression analyses showed a strong relationship between the quartiles of apoB level and more-than-a-moderate risk and high risk group, respectively. These associations were attenuated, but still remained statistically significant. ApoB is found to be independently related to the risk of CHD using FRS in healthy Korean men, and the link between apoB and the risk of CHD is dose-dependent.
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Registered trials
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