Evidence map›Paper›PMID 21532581›Full record

ArticleNature methods2011

Analysis of repetitive DNA in chromosomes by flow cytometry.

Julie Brind'Amour, Peter M Lansdorp

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Nature methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

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  11. Chromosomes in the flow to simplify genome analysis.Functional & integrative genomics · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Julie Brind'AmourTerry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Peter M Lansdorp
BC Cancer Agency · CAUniversity of British Columbia · CA

Funding

Chromatin maintenance and sister chromatid differentiationR01GM094146 · NIGMS · BRITISH COLUMBIA CANCER AGENCY · PI LANSDORP, PETER M · 2010 to 2013
$929k
CIHR RMF-92093NIGMS NIH HHS R01 GM094146NIGMS NIH HHS R01GM094146
6 · The paper itself

Abstract

We developed a flow cytometry method, chromosome flow fluorescence in situ hybridization (FISH), called CFF, to analyze repetitive DNA in chromosomes using FISH with directly labeled peptide nucleic acid (PNA) probes. We used CFF to measure the abundance of interstitial telomeric sequences in Chinese hamster chromosomes and major satellite sequences in mouse chromosomes. Using CFF we also identified parental homologs of human chromosome 18 with different amounts of repetitive DNA.

Indexed as

Repetitive Sequences, Nucleic AcidAnimalsBase SequenceChromosomesChromosomes, Human, Pair 18CricetinaeCricetulusDNADNA, SatelliteFlow CytometryHumansIn Situ Hybridization, FluorescenceMiceOligonucleotide ProbesPeptide Nucleic AcidsTelomereDNADNA, SatelliteOligonucleotide ProbesPeptide Nucleic Acids

Identifiers

PMID21532581
PMCPMC3753228
OpenAlexW2122575659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.