ArticleProceedings of the National Academy of Sciences of the United States of America2011
Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.Brain imaging and behavior · 2013Pooled it
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- Pseudogenes in Cancer: State of the Art.Cancers · 2023Review
- Enhanced genome-wide association reveals the role of YABBY11-NGATHA-LIKE1 in leaf serration development of Populus.Plant physiology · 2023Article
- Current Status of Regulatory Non-Coding RNAs Research in the Tritryp.Non-coding RNA · 2022Review
- Cancer, Retrogenes, and Evolution.Life (Basel, Switzerland) · 2021Review
- Pseudogenes: Four Decades of Discovery.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Article
- Identification of Potential Diagnostic and Prognostic Pseudogenes in Hepatocellular Carcinoma Based on Pseudogene-miRNA-mRNA Competitive Network.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Re-recognition of pseudogenes: From molecular to clinical applications.Theranostics · 2020Review
- lncRNA-PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway.Molecular oncology · 2019Article
- Extensive profiling inRNA (New York, N.Y.) · 2019Article
- Pseudogene CHIAP2 inhibits proliferation and invasion of lung adenocarcinoma cells by means of the WNT pathway.Journal of cellular physiology · 2019Article
- Evolutionary Origins of Pseudogenes and Their Association with Regulatory Sequences in Plants.The Plant cell · 2019Article
- Suppressors of RNA silencing encoded by geminiviruses and associated DNA satellites.Virusdisease · 2019Article
- Origination and Function of Plant Pseudogenes.Plant signaling & behavior · 2019Article
- Role of Pseudogenes in Tumorigenesis.Cancers · 2018Review
- dreamBase: DNA modification, RNA regulation and protein binding of expressed pseudogenes in human health and disease.Nucleic acids research · 2018Article
- Genome Plasticity in CulturedFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudogenes have been shown to acquire unique regulatory roles from more and more organisms. We report the observation of a cluster of siRNAs derived from pseudogenes of African Trypanosoma brucei using high through-put analysis. We show that these pseudogene-derived siRNAs suppress gene expression through RNA interference. The discovery that siRNAs may originate from pseudogenes and regulate gene expression in a unicellular eukaryote provides insights into the functional roles of pseudogenes and into the origin of noncoding small RNAs.
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