Evidence map›Paper›PMID 21531880›Full record

ArticleMayo Clinic proceedings2011

Prevalence of airway obstruction assessed by lung function questionnaire.

Matthew L Mintz, Barbara P Yawn, David M Mannino, James F Donohue, Nicola A Hanania, Catherine A Grellet, Alicia W Gilsenan, Lori D McLeod, Anand A Dalal, Ibrahim H Raphiou and 4 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Mayo Clinic proceedings, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01013948 (Prevalence of Chronic Airway Onstruction in a Subject Population With a History of Cigarette Smoking in a Primary Care Setting), which is not on this map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01013948 completednot on this map

Prevalence of Chronic Airway Onstruction in a Subject Population With a History of Cigarette Smoking in a Primary Care Setting

TypeobservationalSponsorGlaxoSmithKlineRan2009 to 2009Enrolled1,574ConditionsPulmonary Disease, Chronic ObstructiveArmsNon-Interventional
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Case finding for COPD in primary care: a systematic review.Primary care respiratory journal : journal of the General Practice Airways Group · 2012
    Pooled it
  5. Case finding for chronic obstructive pulmonary disease in primary care: a pilot randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2013
    Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Matthew L MintzDepartment of Medicine, George Washington University School of Medicine, Washington, DC, USA.
Barbara P Yawn
David M Mannino
James F Donohue
Nicola A Hanania
Catherine A Grellet
Alicia W Gilsenan
Lori D McLeod
Anand A Dalal
Ibrahim H Raphiou
Barbara A Prillaman
Glenn D Crater
Michael J Cicale
Douglas W Mapel

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo estimate the prevalence of unidentified chronic obstructive pulmonary disease (COPD) and determine the screening accuracy of the Lung Function Questionnaire (LFQ). PATIENTS AND

methodsCigarette smokers who had a smoking history of 10 or more pack-years and were aged 30 years or older were recruited from 36 centers from February 18, 2009, to May 29, 2009. A total of 1575 patients completed a Web-based survey including the 5-item LFQ. Spirometry was performed on patients with an LFQ total score of 18 or less and on a subset scoring more than 18. The primary outcome was the proportion of patients at risk of airflow obstruction as measured by the LFQ (score, ≤ 18) in whom an airflow obstruction was confirmed by spirometry.

resultsOf the patients who completed the LFQ, 849 (54%) had standardized spirometry data available. On the basis of LFQ and spirometry results, the estimated prevalence of possible COPD was 17.9% (95% confidence interval, 15.3%-20.6%). At a cut point of 18 or less, sensitivity, specificity, positive predictive value, and negative predictive value of the LFQ were 88%, 25%, 21%, and 90%, respectively. Approximately 1 in 5 patients (21%) aged 30 years or older and 1 in 4 (26%) aged 50 years or older scored 18 or less on the LFQ and had a ratio of forced expiratory volume in the first second of expiration to forced vital capacity less than 0.70.

conclusionOn the basis of postbronchodilator spirometry results using weighted estimates, approximately 1 in 5 patients (21%) aged 30 years or older with a smoking history of 10 or more pack-years seen in a primary care setting is likely to have COPD. The LFQ could be a helpful COPD case-finding tool for clinicians to identify patients who need further evaluation.

trial registrationclinicaltrials.gov Identifier: NCT01013948.

Indexed as

InternetSurveys and QuestionnairesAdultAgedAirway ObstructionCross-Sectional StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsPrevalencePrimary Health CarePsychometricsPulmonary Disease, Chronic ObstructiveRisk Assessment

Identifiers

PMID21531880
PMCPMC3084639

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.