ArticleNeurobiology of aging2012
Maximal brain size remains an important predictor of cognition in old age, independent of current brain pathology.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is intracranial volume a suitable proxy for brain reserve?Alzheimer's research & therapy · 2018Pooled it
- Precuneus and Cingulate Cortex Atrophy and Hypometabolism in Patients with Alzheimer's Disease and Mild Cognitive Impairment: MRI and (18)F-FDG PET Quantitative Analysis Using FreeSurfer.BioMed research international · 2015Trial
- Disentangling the effect of sex from brain size on brain organization and cognitive functioning.GeroScience · 2025Article
- Structural deviations of the posterior fossa and the cerebellum and their cognitive links in a neurodevelopmental deletion syndrome.Molecular psychiatry · 2024Article
- Intracranial Volume Is Driven by Both Genetics and Early Life Exposures: The SOL-INCA-MRI Study.Ethnicity & disease · 2024Article
- Proportional intracranial volume correction differentially biases behavioral predictions across neuroanatomical features, sexes, and development.NeuroImage · 2022Article
- Generalizing deep learning brain segmentation for skull removal and intracranial measurements.Magnetic resonance imaging · 2022Article
- Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline.Neurology · 2022Article
- Association of Social Support With Brain Volume and Cognition.JAMA network open · 2021Article
- Dual-task performance is associated with brain MRI Morphometry in individuals with mild cognitive impairment.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
- Convolutional Neural Net Learning Can Achieve Production-Level Brain Segmentation in Structural Magnetic Resonance Imaging.Frontiers in neuroscience · 2021Article
- Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.Neurobiology of aging · 2019Article
- Structural covariance across the lifespan: Brain development and aging through the lens of inter-network relationships.Human brain mapping · 2019Article
- Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment.PLoS genetics · 2018Article
- Education, bilingualism, and cognitive trajectories: Sacramento Area Latino Aging Study (SALSA).Neuropsychology · 2018Article
- Simultaneous total intracranial volume and posterior fossa volume estimation using multi-atlas label fusion.Human brain mapping · 2017Article
- Novel genetic loci underlying human intracranial volume identified through genome-wide association.Nature neuroscience · 2016Article
- Structural Brain MRI Trait Polygenic Score Prediction of Cognitive Abilities.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2015Article
- Automated CT-based segmentation and quantification of total intracranial volume.European radiology · 2015Article
- Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease.Human brain mapping · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
There is growing interest in the influence of early-life development on clinical manifestations of late-life diseases. Latent variable modeling was used to investigate how maximal brain volume (measured by intracranial volume [ICV]) and current brain volumes uniquely contribute to domain-specific cognitive performance in a group of 401 cognitively and ethnically diverse older adults. Individual effects of volumetric magnetic resonance imaging (MRI) measures including ICV were examined as predictors of episodic memory, semantic memory, spatial ability, and executive function. Total brain matter volume related to all cognitive domains; hippocampal volume was associated primarily with episodic memory; white matter hyperintensity volume was related to executive function and episodic memory. Maximal brain size as measured by ICV was related to semantic memory, executive function, and spatial ability independent of current brain volumes (ps < 0.01). Relationships between magnetic resonance imaging (MRI) variables and cognition did not differ substantially across groups defined by ethnicity, gender, and with minor exceptions, clinical diagnosis. Results suggest maximal brain development and measures of brain injury/atrophy jointly contribute to cognitive function in older people.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.