ReviewProgress in neurobiology2011
Function and mechanism of axonal targeting of voltage-sensitive potassium channels.
Review in Progress in neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 48 citations in OpenAlex.
- Proper localization of the SCA13-linked KNeurobiology of disease · 2026Article
- Adaptations of the axon initial segment in fast-spiking interneurons of the human neocortex support low action potential thresholds.PLoS biology · 2025Article
- A novel mechanism for short-term post-tetanic plasticity in thalamocortical neurons.Brain research · 2025Article
- Discovering functional interactions among schizophrenia-risk genes by combining behavioral genetics with cell biology.Neuroscience and biobehavioral reviews · 2024Review
- A cytoskeleton-membrane interaction conserved in fast-spiking neurons controls movement, emotion, and memory.Molecular psychiatry · 2023Article
- Analysis of Potential Hub Genes for Neuropathic Pain Based on Differential Expression in Rat Models.Pain research & management · 2022Article
- Wireless Localized Electrical Stimulation Generated by an Ultrasound-Driven Piezoelectric Discharge Regulates Proinflammatory Macrophage Polarization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Smart motors and cargo steering drive kinesin-mediated selective transport.Molecular and cellular neurosciences · 2020Review
- The Interstitial System of the Brain in Health and Disease.Aging and disease · 2020Review
- Balanced Activity between Kv3 and Nav Channels Determines Fast-Spiking in Mammalian Central Neurons.iScience · 2018Article
- Gain control with A-type potassium current: IA as a switch between divisive and subtractive inhibition.PLoS computational biology · 2018Article
- Article
- Suppression of Inflammatory Demyelinaton and Axon Degeneration through Inhibiting Kv3 Channels.Frontiers in molecular neuroscience · 2017Article
- The cellular mechanisms that maintain neuronal polarity.Nature reviews. Neuroscience · 2016Review
- Inhibitory modulation of optogenetically identified neuron subtypes in the rostral solitary nucleus.Journal of neurophysiology · 2016Article
- Article
- Effects of high-fat diet and gastric bypass on neurons in the caudal solitary nucleus.Physiology & behavior · 2015Article
- Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Loss of auditory activity modifies the location of potassium channel KCNQ5 in auditory brainstem neurons.Journal of neuroscience research · 2015Article
- Combination of electroacupuncture and grafted mesenchymal stem cells overexpressing TrkC improves remyelination and function in demyelinated spinal cord of rats.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Precise localization of various ion channels into proper subcellular compartments is crucial for neuronal excitability and synaptic transmission. Axonal K(+) channels that are activated by depolarization of the membrane potential participate in the repolarizing phase of the action potential, and hence regulate action potential firing patterns, which encode output signals. Moreover, some of these channels can directly control neurotransmitter release at axonal terminals by constraining local membrane excitability and limiting Ca(2+) influx. K(+) channels differ not only in biophysical and pharmacological properties, but in expression and subcellular distribution as well. Importantly, proper targeting of channel proteins is a prerequisite for electrical and chemical functions of axons. In this review, we first highlight recent studies that demonstrate different roles of axonal K(+) channels in the local regulation of axonal excitability. Next, we focus on research progress in identifying axonal targeting motifs and machinery of several different types of K(+) channels present in axons. Regulation of K(+) channel targeting and activity may underlie a novel form of neuronal plasticity. This research field can contribute to generating novel therapeutic strategies through manipulating neuronal excitability in treating neurological diseases, such as multiple sclerosis, neuropathic pain, and Alzheimer's disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.