Evidence map›Paper›PMID 21530232›Full record

ReviewCurrent opinion in genetics & development2011

RNA structure and the mechanisms of alternative splicing.

C Joel McManus, Brenton R Graveley

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed.

  1. Alternative splicing dynamics in pig tissues under soybean oil supplementation.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. The "cutting edge" of non-canonical RNA splicing.Frontiers in molecular biosciences · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Control of gene output by intron RNA structure.bioRxiv : the preprint server for biology · 2025
    Article
  12. CAR-SPLASH identifies nascent pre-mRNA structures implicated in kinetic coupling and alternative splicing.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Functions and therapeutic applications of pseudouridylation.Nature reviews. Molecular cell biology · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Pre-mRNA Splicing Modulation by Antisense Oligonucleotides.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  20. Review

74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

C Joel McManusDepartment of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, 400 Farmington Avenue, Farmington, CT 06030, USA.
Brenton R Graveley

Funding

Alternative Splicing of the Drosophilia Dscam Pre-mRNAR01GM067842 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R. · 2003 to 2014
$3.6M
The Mechanisms and Regulatory Networks of Alternative Splicing in DrosophilaR01GM062516 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R. · 2001 to 2009
$2.6M
Trans-Splicing in DrosophilaR01GM095296 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GRAVELEY, BRENTON R. · 2011 to 2014
$1.6M
NIGMS NIH HHS R01 GM062516NIGMS NIH HHS R01 GM067842NIGMS NIH HHS R01 GM095296
6 · The paper itself

Abstract

Alternative splicing is a widespread means of increasing protein diversity and regulating gene expression in eukaryotes. Much progress has been made in understanding the proteins involved in regulating alternative splicing, the sequences they bind to, and how these interactions lead to changes in splicing patterns. However, several recent studies have identified other players involved in regulating alternative splicing. A major theme emerging from these studies is that RNA secondary structures play an under appreciated role in the regulation of alternative splicing. This review provides an overview of the basic aspects of splicing regulation and highlights recent progress in understanding the role of RNA secondary structure in this process.

Indexed as

Alternative SplicingAnimalsGene Expression RegulationHumansNucleic Acid ConformationRNA-Binding ProteinsRNA, MessengerSpliceosomesRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID21530232
PMCPMC3149766

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.