ReviewCurrent opinion in genetics & development2011
Translational regulation in growth cones.
Review in Current opinion in genetics & development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.RNA (New York, N.Y.) · 2020Article
- miR-92 Suppresses Robo1 Translation to Modulate Slit Sensitivity in Commissural Axon Guidance.Cell reports · 2018Article
- BDNF Reduces eEF2 Phosphorylation and Enhances Novel Protein Synthesis in the Growth Cones of Dorsal Root Ganglia Neurons.Neurochemical research · 2018Article
- ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis.Open biology · 2016Article
- A Serotonin Circuit Acts as an Environmental Sensor to Mediate Midline Axon Crossing through EphrinB2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.Molecular and cellular biology · 2015Article
- The Abl/enabled signaling pathway regulates Golgi architecture in Drosophila photoreceptor neurons.Molecular biology of the cell · 2014Article
- A developmental approach to predicting neuronal connectivity from small biological datasets: a gradient-based neuron growth model.PloS one · 2014Article
- microRNAs in axon guidance.Frontiers in cellular neuroscience · 2014Review
- Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localization.RNA (New York, N.Y.) · 2013Article
- Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization.The Journal of cell biology · 2013Article
- Mitochondrial Dynamics in Retinal Ganglion Cell Axon Regeneration and Growth Cone Guidance.Journal of ocular biology · 2013Article
- Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2.PLoS biology · 2013Article
- Axonal transport of neural membrane protein 35 mRNA increases axon growth.Journal of cell science · 2013Article
- Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy.Nature neuroscience · 2012Article
- Mitochondrial dynamics regulate growth cone motility, guidance, and neurite growth rate in perinatal retinal ganglion cells in vitro.Investigative ophthalmology & visual science · 2012Article
- The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.Human molecular genetics · 2012Article
- Spinal muscular atrophy: the role of SMN in axonal mRNA regulation.Brain research · 2012Review
- Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation.PLoS biology · 2012Article
- miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigating retinal growth cones.Nature neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Axonal growth cones (GCs) steer in response to extrinsic cues using mechanisms that include local protein synthesis. This adaptive form of gene regulation occurs with spatial precision and depends on subcellular mRNA localisation. Recent genome-wide studies have shown unexpectedly complex and dynamically changing mRNA repertoires in growing axons and GCs. Axonal targeting of some transcripts seems to be highly selective and involves sequence diversity in non-coding regions generated by transcriptional and/or post-transcriptional mechanisms. New evidence reports direct coupling of a guidance receptor to the protein synthesis machinery and other findings demonstrate that some guidance cues can repress translation. The recent findings shed further light on the exquisitely regulated process that enables distant cellular compartments to respond to local stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.