ArticleActa histochemica2012
Quantification of collagen organization using fractal dimensions and Fourier transforms.
Article in Acta histochemica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 71 citations in OpenAlex.
- Association of tumor associated collagen signature with lymph node metastasis in pancreatic ductal adenocarcinoma.Bioengineering & translational medicine · 2026Article
- Application ofActa histochemica et cytochemica · 2026Article
- Imaging the extracellular matrix structure and remodeling in healthy, fibrotic, and emphysematous human precision-cut lung slices.Respiratory research · 2025Article
- Partial cystectomy as a surgical option for colorectal cancer patients with pathological bladder invasion: an original retrospective study.Therapeutic advances in gastroenterology · 2025Article
- Physiological mechanical forces accelerate the degradation of bovine lung collagen fibers by bacterial collagenase.Scientific reports · 2024Article
- Label-Free Monitoring of Endometrial Cancer Progression Using Multiphoton Microscopy.Annals of biomedical engineering · 2024Article
- A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration.NPJ Regenerative medicine · 2024Article
- Nomograms integrating the collagen signature and systemic immune-inflammation index for predicting prognosis in rectal cancer patients.BJS open · 2024Article
- Unveiling breast cancer metastasis through an advanced X-ray imaging approach.Scientific reports · 2024Article
- Three-dimensional cell culture conditions promoted the Mesenchymal-Amoeboid Transition in the Triple-Negative Breast Cancer cell line MDA-MB-231.Frontiers in cell and developmental biology · 2024Article
- High-resolution confocal and light-sheet imaging of collagen 3D network architecture in very large samples.iScience · 2023Article
- Fractal analysis is a useful tool for evaluating prostate tissue remodeling caused by ethanol consumption and androgen therapy.Animal reproduction · 2023Article
- Fractal analysis of rat dermal tissue in the different injury states.International wound journal · 2022Article
- Hyperspectral evaluation of vasculature in induced peritonitis mouse models.Biomedical optics express · 2022Article
- Computer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer.BMC medicine · 2021Article
- Development and validation of a collagen signature-based nomogram for preoperatively predicting lymph node metastasis and prognosis in colorectal cancer.Annals of translational medicine · 2021Article
- Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram.Nature communications · 2021Article
- Exosome-educated macrophages and exosomes differentially improve ligament healing.Stem cells (Dayton, Ohio) · 2021Article
- Fractal analysis of concurrently prepared latex rubber casts of the bronchial and vascular systems of the human lung.Open biology · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Collagen fibers and fibrils that comprise tendons and ligaments are disrupted or damaged during injury. Fibrillogenesis during healing produces a matrix that is initially quite disorganized, but remodels over time to resemble, but not replicate, the original roughly parallel microstructure. Quantification of these changes is traditionally a laborious and subjective task. In this work we applied two automated techniques, fast Fourier transformation (FFT) and fractal dimension analysis (FA) to quantify the organization of collagen fibers or fibrils. Using multi-photon images of collagen fibers obtained from rat ligament we showed that for healing ligaments, FA differentiates more clearly between the different time-points during healing. Using scanning electron microscopy images of overstretched porcine flexor tendon, we showed that combining FFT and FA measures distinguishes the damaged and undamaged groups more clearly than either method separately.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.