ArticleThe Journal of surgical research2012
A low mortality model of chronic pulmonary hypertension in sheep.
Article in The Journal of surgical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Animal models of chronic thromboembolic pulmonary hypertension.Animal models and experimental medicine · 2026Review
- Recovery of extracorporeal lungs using cross-circulation with injured recipient swine.The Journal of thoracic and cardiovascular surgery · 2024Article
- A Dynamic Sheep Model to Induce Pulmonary Hypertension and Right Ventricular Failure.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Progression Toward Decompensated Right Ventricular Failure in the Ovine Pulmonary Hypertension Model.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2022Article
- A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep.Journal of visualized experiments : JoVE · 2021Article
- Back to the root: a large animal model of the Ross procedure.Annals of cardiothoracic surgery · 2021Review
- Chronic Thromboembolic Pulmonary Hypertension - What Have We Learned From Large Animal Models.Frontiers in cardiovascular medicine · 2021Review
- Cardiorespiratory physiological perturbations after acute smoke-induced lung injury and during extracorporeal membrane oxygenation support in sheep.F1000Research · 2020Article
- Variability of the Sheep Lung Microbiota.Applied and environmental microbiology · 2016Article
- Combination proximal pulmonary artery coiling and distal embolization induces chronic elevations in pulmonary artery pressure in Swine.PloS one · 2015Article
- Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization.Heart rhythm · 2012Article
- Pediatric Artificial Lung: A Low-Resistance Pumpless Artificial Lung Alleviates an Acute Lamb Model of Increased Right Ventricle Afterload.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
- The Implantable Pediatric Artificial Lung: Interim Report on the Development of an End-Stage Lung Failure Model.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
- Hemodynamic design requirements for in-series thoracic artificial lung attachment in a model of pulmonary hypertension.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPulmonary hypertension and right ventricular failure are major contributors to morbidity and mortality in chronic lung disease. Therefore, large animal models of pulmonary hypertension and right ventricular hypertrophy are needed to study underlying disease mechanisms and test new treatment modalities. The objective of this study was to create a low-mortality model of chronic pulmonary hypertension and right ventricular hypertrophy in sheep.
methodsThe vena cavae of nine sheep weighing 62 ± 2 (SEM) kg were injected with 0.375 g of dextran beads (sephadex) every day for 60 d. Pulmonary hemodynamics were assessed via pulmonary artery catheterization prior to the first injection and again on d 14, 28, 35, 42, 49, and 56. At the end of the experiment, the heart was removed, dissected, and weighed to determine the ratio of right ventricular mass to left ventricle plus septal mass (RV:LV+S).
resultsAll sheep survived to 60 d. The average pulmonary artery pressure rose from 17 ± 1 mmHg at baseline to 35 ± 3 mmHg on d 56 with no significant change in cardiac output (8.7 ± 0.7 to 9.8 ± 0.7 L/min, P = 0.89). The RV:LV+S was significantly higher (0.42 ± 0.01, P < 0.001) than a historic group of untreated normal animals (0.35 ± 0.01, n = 13).
conclusionThis study provides a low-mortality large animal model of moderate chronic pulmonary hypertension and right ventricular hypertrophy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.