ArticleThe Journal of surgical research2011
Hemorrhagic shock induces a proinflammatory milieu in the gut lumen.
Article in The Journal of surgical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Friend or foe: the gut microbiota as a modulator of disease trajectory in trauma, surgery, and critical illness.Gut microbes · 2025Review
- How Delayed Cord Clamping Saves Newborn Lives.Children (Basel, Switzerland) · 2025Review
- Navigating Hemorrhagic Shock: Biomarkers, Therapies, and Challenges in Clinical Care.Biomedicines · 2024Review
- Cardiac Asystole at Birth Re-Visited: Effects of Acute Hypovolemic Shock.Children (Basel, Switzerland) · 2023Review
- Brain Death-Induced Inflammatory Activity is Similar to Sepsis-Induced Cytokine Release.Cell transplantation · 2018Article
- Metformin Exerts Beneficial Effects in Hemorrhagic Shock in An AMPKα1-Independent Manner.Shock (Augusta, Ga.) · 2018Article
- Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic Injury.Mediators of inflammation · 2015Review
- Simulated aeromedical evacuation does not affect systemic inflammation or organ injury in a murine model of hemorrhagic shock.Military medicine · 2012Article
- Proinflammatory chemokines in the intestinal lumen contribute to intestinal dysfunction during endotoxemia.Shock (Augusta, Ga.) · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIntestinal injury is a consequence of hemorrhagic shock and resuscitation. The intestinal mucosa has been shown to respond to ischemia/reperfusion injury with production of inflammatory mediators. Previous work in our laboratory indicates that intestinal epithelial cells secrete proinflammatory cytokines in the direction of both the lamina propria and intestinal lumen. The ability of the intestinal mucosa to transmit inflammatory signals into the gut lumen after hemorrhagic shock is unknown. We hypothesized that hemorrhagic shock results in secretion of proinflammatory cytokines into the gut lumen.
methodsMale C57/Bl6 mice underwent femoral artery cannulation and hemorrhage to a systolic blood pressure of 20 mmHg for 1 h, then resuscitation with lactated Ringer's (LR) solution. Sham animals were cannulated only. Mice were decannulated and sacrificed at intervals. Stool and succus were removed from intestinal segments, weighed, and placed into buffer solution. Specimens were analyzed via enzyme-linked immunosorbent assay (ELISA).
resultsCompared with sham-injured mice, hemorrhagic shock resulted in increased intestinal luminal cytokines. At 3 h after injury, elevated levels of IL-6 were found in the cecal stool. At 6 h after injury, TNFα, IL-6, and MIP-2 were significantly elevated in the cecal stool, and IL-6 and MIP-2 were significantly elevated in the distal colonic stool.
conclusionsHemorrhagic shock results in secretion of proinflammatory cytokines into the intestinal lumen. These findings suggest that the intestinal mucosa may transmit and receive signals in a paracrine fashion via the gut lumen.
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