ArticleThe Journal of surgical research2011
Race disparities in Wilms tumor incidence and biology.
Article in The Journal of surgical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Global burden and temporal trends of kidney cancer among children from 1990 to 2021: an analysis with projections to 2036.Frontiers in pediatrics · 2026Article
- Long-term kidney outcomes in survivors of Wilms tumor: a single-center retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Incidence and Survival of Children and Adolescents With Wilms Tumor, United States, 2001-2020.Cancer medicine · 2025Article
- Inter-Ethnic Variations in the Clinical, Pathological, and Molecular Characteristics of Wilms Tumor.Cancers · 2024Review
- A population-based study on incidence trends of kidney and renal pelvis cancers in the United States over 2000-2020.Scientific reports · 2024Article
- Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin.Communications biology · 2024Article
- Race, ethnicity, and socioeconomic differences in incidence of pediatric embryonal tumors in the United States.Pediatric blood & cancer · 2020Article
- Wilms Tumor in Sub-Saharan Africa: Molecular and Social Determinants of a Global Pediatric Health Disparity.Frontiers in oncology · 2020Review
- Neurocognitive outcomes in long-term survivors of Wilms tumor: a report from the St. Jude Lifetime Cohort.Journal of cancer survivorship : research and practice · 2019Article
- Pediatric Solid Tumors in Resource-Constrained Settings: A Review of Available Evidence on Management, Outcomes, and Barriers to Care.Children (Basel, Switzerland) · 2018Review
- Prostate cancer health disparities: An immuno-biological perspective.Cancer letters · 2018Article
- Label-free molecular imaging of the kidney.Kidney international · 2017Review
- Childhood cancer incidence by ethnic group in England, 2001-2007: a descriptive epidemiological study.BMC cancer · 2017Article
- Pathology interface for the molecular analysis of tissue by mass spectrometry.Journal of pathology informatics · 2016Article
- Peptide spectra in Wilms tumor that associate with adverse outcomes.The Journal of surgical research · 2015Article
- Nephroblastoma--a 25-year review of a South African unit.Journal of medicine and life · 2014Review
- Race disparities in peptide profiles of North American and Kenyan Wilms tumor specimens.Journal of the American College of Surgeons · 2014Article
- Wilms tumor survival in Kenya.Journal of pediatric surgery · 2013Article
- Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research.Chemical reviews · 2013Review
- Molecular characterization of Wilms' tumor from a resource-constrained region of sub-Saharan Africa.International journal of cancer · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWilms tumor (WT) is thought to arise in children of Black African ancestry with greater frequency than in Whites. To clarify the biological basis for race disparities in WT, we first verified that Black children residing in Tennessee have an increased incidence of WT, and second, established molecular profiles in WT that are specific to race. MATERIALS AND
methodsTo assess race disparities in WT epidemiology, the Tennessee Cancer Registry (TCR) was queried for all in-state patients less than 20 y of age and registered between 1999 and 2008. To explore race disparities in WT biology, six Black and four White WT specimens acquired in Tennessee were analyzed using imaging mass spectrometry (IMS).
resultsTCR data show that Black children are over-represented among WT patients (29%) relative to all other childhood cancers (18.5%; P = 0.01). WT ranked the fifth most common cancer diagnosis among Blacks, but ninth among Whites. The diagnosis of WT occurred 79% more frequently among Blacks (n = 28) than Whites (n = 69; P = 0.01), and proportionally more Blacks tended to present with distant disease. Although overall survival from WT was not statistically different between Blacks (92.9%) and Whites (94.0%), Black males showed the lowest survival (85%; P = 0.21). IMS analysis identified peptide spectra from both WT blastema and stroma that independently classify specimens according to race with greater than 80% accuracy.
conclusionsIn Tennessee, Black children appear more susceptible than Whites to develop WT. Race-specific molecular profiles can be determined that may help to clarify pathways of Wilms tumorigenesis and the biological basis for race disparities in WT incidence and biology.
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