ArticleBiological psychiatry2011
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.
Article in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 12 of them syntheses that pooled it.
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Who cites it
132 citing papers in PubMed, 12 syntheses or guidelines pooled it, 199 citations in OpenAlex.
- Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.Nature medicine · 2023Pooled it
- The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews.Psychological bulletin · 2021Pooled it
- Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics.Journal of studies on alcohol and drugs · 2016Pooled it
- The association between childhood maltreatment, psychopathology, and adult sexual victimization in men and women: results from three independent samples.Psychological medicine · 2016Pooled it
- A New Genomewide Association Meta-Analysis of Alcohol Dependence.Alcoholism, clinical and experimental research · 2015Pooled it
- Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2015Pooled it
- Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans.Alcoholism, clinical and experimental research · 2015Pooled it
- Genome-wide association study of blood lead shows multiple associations near ALAD.Human molecular genetics · 2015Pooled it
- Association of gamma-aminobutyric acid A receptor α2 gene (GABRA2) with alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Pooled it
- A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Human genetics · 2013Pooled it
- Genome-wide association study identifies loci affecting blood copper, selenium and zinc.Human molecular genetics · 2013Pooled it
- Genome-wide association discoveries of alcohol dependence.The American journal on addictionsPooled it
- Life without sex: Large-scale study links sexlessness to physical, cognitive, and personality traits, socioecological factors, and DNA.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Uncovering genetic mechanisms associated with harmful use of alcohol in admixed Latin Americans.BMC genomics · 2025Article
- Pre-existing DNA methylation signatures in the prefrontal cortex of alcohol-naïve nonhuman primates define neural vulnerability for future risky ethanol consumption.Neurobiology of disease · 2025Article
- Epigenetic Dysregulation in Alcohol-Associated Behaviors: Preclinical and Clinical Evidence.Current topics in behavioral neurosciences · 2025Review
- Human genetics and epigenetics of alcohol use disorder.The Journal of clinical investigation · 2024Review
- RNA alternative splicing impacts the risk for alcohol use disorder.Molecular psychiatry · 2023Article
- The association between theArhiv za higijenu rada i toksikologiju · 2023Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundGiven moderately strong genetic contributions to variation in alcoholism and heaviness of drinking (50% to 60% heritability) with high correlation of genetic influences, we have conducted a quantitative trait genome-wide association study (GWAS) for phenotypes related to alcohol use and dependence.
methodsDiagnostic interview and blood/buccal samples were obtained from sibships ascertained through the Australian Twin Registry. Genome-wide single nucleotide polymorphism (SNP) genotyping was performed with 8754 individuals (2062 alcohol-dependent cases) selected for informativeness for alcohol use disorder and associated quantitative traits. Family-based association tests were performed for alcohol dependence, dependence factor score, and heaviness of drinking factor score, with confirmatory case-population control comparisons using an unassessed population control series of 3393 Australians with genome-wide SNP data.
resultsNo findings reached genome-wide significance (p = 8.4 × 10(-8) for this study), with lowest p value for primary phenotypes of 1.2 × 10(-7). Convergent findings for quantitative consumption and diagnostic and quantitative dependence measures suggest possible roles for a transmembrane protein gene (TMEM108) and for ANKS1A. The major finding, however, was small effect sizes estimated for individual SNPs, suggesting that hundreds of genetic variants make modest contributions (1/4% of variance or less) to alcohol dependence risk.
conclusionsWe conclude that 1) meta-analyses of consumption data may contribute usefully to gene discovery; 2) translation of human alcoholism GWAS results to drug discovery or clinically useful prediction of risk will be challenging; and 3) through accumulation across studies, GWAS data may become valuable for improved genetic risk differentiation in research in biological psychiatry (e.g., prospective high-risk or resilience studies).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.