ReviewBiological psychiatry2011
Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: developing imaging biomarkers to enhance treatment development for schizophrenia and related disorders.
Review in Biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Threats to external validity in the neuroprediction of substance use treatment outcomes.The American journal of drug and alcohol abuse · 2023Pooled it
- Task-related fMRI responses to a nicotinic acetylcholine receptor partial agonist in schizophrenia: A randomized trial.Progress in neuro-psychopharmacology & biological psychiatry · 2016Trial
- From facing fears to experimental frontiers: immersive cinematic virtual reality environments as a catalyst for innovation in behavioral neuroscience.Frontiers in psychiatry · 2026Article
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
- Neural underpinnings of memory encoding and retrieval: Validation of a novel ecologically valid fMRI paradigm.Neuroscience applied · 2024Article
- An Update on Promising Biomarkers in Schizophrenia.Focus (American Psychiatric Publishing) · 2018Review
- Enhancing the Informativeness and Replicability of Imaging Genomics Studies.Biological psychiatry · 2017Review
- Transdiagnostic neural markers of emotion-cognition interaction in psychotic disorders.Journal of abnormal psychology · 2016Article
- A Roadmap for the Development of Applied Computational Psychiatry.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- Disconnection Between Amygdala and Medial Prefrontal Cortex in Psychotic Disorders.Schizophrenia bulletin · 2016Article
- A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I.Annals of clinical and translational neurology · 2016Article
- Translational Rodent Paradigms to Investigate Neuromechanisms Underlying Behaviors Relevant to Amotivation and Altered Reward Processing in Schizophrenia.Schizophrenia bulletin · 2015Review
- Investigating the mechanism(s) underlying switching between states in bipolar disorder.European journal of pharmacology · 2015Review
- Cognitive abilities on transitive inference using a novel touchscreen technology for mice.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Developing treatments for cognitive deficits in schizophrenia: the challenge of translation.Journal of psychopharmacology (Oxford, England) · 2015Review
- Neuroimaging biomarkers for early drug development in schizophrenia.Biological psychiatry · 2014Review
- A potential electroencephalography and cognitive biosignature for the child behavior checklist-dysregulation profile.Journal of the American Academy of Child and Adolescent Psychiatry · 2013Article
- Nicotinic modulation of intrinsic brain networks in schizophrenia.Biochemical pharmacology · 2013Review
- A review of recent literature employing electroencephalographic techniques to study the pathophysiology, phenomenology, and treatment response of schizophrenia.Current psychiatry reports · 2013Review
- Semantic association fMRI impairments represent a potential schizophrenia biomarker.Schizophrenia research · 2013Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative, funded by an R13 from the National Institute of Mental Health, seeks to enhance translational research in treatment development for impaired cognition in schizophrenia by developing tools from cognitive neuroscience into useful measures of treatment effects on behavior and brain function. An initial series of meetings focused on the selection of a new set of tasks from cognitive neuroscience for the measurement of treatment effects on specific cognitive and neural systems. Subsequent validation and optimization studies are underway and a subset of validated measures with well-characterized psychometric properties will be generally available in 2011. This article describes results of the first meeting of the second phase of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia, which seeks to develop imaging biomarkers and improved animal models to enhance translational research. In this meeting, we considered issues related to the use of methods such as functional magnetic resonance imaging, electroencephalography, magnetoencephalography, and transcranial magnetic simulation as biomarkers for treatment development. We explored the biological nature of the signals measured by each method, their validity and reliability as measures of cognition-related neural activity, potential confounds related to drug effects on the signal of interest, and conceptual, methodological, and pragmatic issues related to their use in preclinical, first into human, and multicenter phase II and III studies. This overview article describes the background and goals of the meeting together with a summary of the major issues discussed in more detail in the accompanying articles appearing in this issue of Biological Psychiatry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.