SynthesisAmerican journal of obstetrics and gynecology2011
Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis.
Synthesis in American journal of obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 6 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- Evaluation of Low-Dose Aspirin on Pregnancy Outcomes: A Systematic Review and Meta-analysis.Archives of Iranian medicine · 2025Pooled it
- Pooled it
- Vitamin C supplementation in pregnancy.The Cochrane database of systematic reviews · 2015Pooled it
- Vitamin E supplementation in pregnancy.The Cochrane database of systematic reviews · 2015Pooled it
- The association between dietary factors and gestational hypertension and pre-eclampsia: a systematic review and meta-analysis of observational studies.BMC medicine · 2014Pooled it
- Antioxidants for preventing preeclampsia: a systematic review.TheScientificWorldJournal · 2012Pooled it
- Effects of prenatal micronutrients supplementation timing on pregnancy-induced hypertension: Secondary analysis of a double-blind randomized controlled trial.Maternal & child nutrition · 2021Trial
- Magnesium supplementation and preeclampsia in low-income pregnant women - a randomized double-blind clinical trial.BMC pregnancy and childbirth · 2020Trial
- Micronutrient supplementation during pregnancy and the risk of pregnancy-induced hypertension: A randomized clinical trial.Clinical nutrition (Edinburgh, Scotland) · 2019Trial
- Prenatal vitamin C and E supplementation in smokers is associated with reduced placental abruption and preterm birth: a secondary analysis.BJOG : an international journal of obstetrics and gynaecology · 2015Trial
- Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts.American journal of physiology. Endocrinology and metabolism · 2012Trial
- What do we know about redox status? A review in neonates of mothers with preeclampsia.Annals of medicine · 2026Review
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- Nutritional supplements for preventing preeclampsia: A network meta-analysis.The Indian journal of medical research · 2026Article
- Preeclampsia trials that changed practice.Seminars in perinatology · 2026Review
- The Risk Factors for Placental Abruption in Preeclamptic Pregnancies: A Retrospective Case-Control Study.The journal of obstetrics and gynaecology research · 2026Article
- Impact of Mediterranean Dietary Intervention on Reactive Oxygen Species Levels and Total Antioxidant Capacity During Pregnancy.Current issues in molecular biology · 2025Article
- Environmental Nephrotoxicity Across the Life Course: Oxidative Stress Mechanisms and Opportunities for Early Intervention.Antioxidants (Basel, Switzerland) · 2025Review
- Pregnancy Under Pressure: Oxidative Stress as a Common Thread in Maternal Disorders.Life (Basel, Switzerland) · 2025Review
- The Role of Mitochondrial Dysfunction and Oxidative Stress in Women's Reproductive Disorders: Implications for Polycystic Ovary Syndrome and Preeclampsia.International journal of molecular sciences · 2025Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo determine whether supplementation with vitamins C and E during pregnancy reduces the risk of preeclampsia and other adverse maternal and perinatal outcomes. STUDY
designSystematic review and metaanalysis of randomized controlled trials.
resultsNine trials involving a total of 19,810 women were included. Overall, there were no significant differences between the vitamin and placebo groups in the risk of preeclampsia (9.6% vs 9.6%; relative risk, 1.00, 95% confidence interval, 0.92-1.09). Similar results were obtained when subgroup analyses were restricted to women at high risk or low/moderate risk for preeclampsia. Women supplemented with vitamins C and E were at increased risk of developing gestational hypertension and premature rupture of membranes, and decreased risk of abruptio placentae. There were no significant differences between the vitamin and placebo groups in the risk of other adverse maternal or fetal/perinatal outcomes.
conclusionSupplementation with vitamins C and E during pregnancy does not prevent preeclampsia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.