ArticleMolecular and cellular biology1990
Cyclic AMP analogs and retinoic acid influence the expression of retinoic acid receptor alpha, beta, and gamma mRNAs in F9 teratocarcinoma cells.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 172 citations in OpenAlex.
- Quantitative Measurement of Relative Retinoic Acid Levels in E8.5 Embryos and Neurosphere Cultures Using the F9 RARE-Lacz Cell-based Reporter Assay.Journal of visualized experiments : JoVE · 2016Article
- Phase I trial of ATRA-IV and Depakote in patients with advanced solid tumor malignancies.Cancer biology & therapy · 2010Article
- Retinoic acid administration and vitamin A status modulate retinoid X receptor alpha and retinoic acid receptor alpha levels in mouse brown adipose tissue.Molecular and cellular biochemistry · 2004Article
- Coordinate regulation of RARgamma2, TBP, and TAFII135 by targeted proteolysis during retinoic acid-induced differentiation of F9 embryonal carcinoma cells.BMC molecular biology · 2001Article
- Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism.Molecular and cellular biology · 1995Article
- Endogenous retinoid X receptors can function as hormone receptors in pituitary cells.Molecular and cellular biology · 1994Article
- Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Expression of cellular retinol- and cellular retinoic acid-binding proteins in the rat cervical epithelium is regulated by endocrine stimuli during normal squamous metaplasia.The American journal of pathology · 1994Article
- Retinoic acid and cyclic AMP synergistically induce the expression of liver/bone/kidney-type alkaline phosphatase gene in L929 fibroblastic cells.The Biochemical journal · 1993Article
- Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes.The Biochemical journal · 1993Article
- Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Characterization of a retinoic acid responsive element isolated by whole genome PCR.Nucleic acids research · 1992Article
- Bone morphogenetic proteins-2 and -4 are involved in the retinoic acid-induced differentiation of embryonal carcinoma cells.Molecular biology of the cell · 1992Article
- Mouse F9 teratocarcinoma stem cells expressing the stably transfected homeobox gene Hox 1.6 exhibit an altered morphology.Gene expression · 1992Article
- Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Retinoid-mediated transcriptional regulation of keratin genes in human epidermal and squamous cell carcinoma cells.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Retinoic acid stimulates the differentiation of PC12 cells that are deficient in cAMP-dependent protein kinase.The Journal of cell biology · 1991Article
- The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element.The EMBO journal · 1991Article
- Retinoic acid increases zif268 early gene expression in rat preosteoblastic cells.Molecular and cellular biology · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Retinoic acid (RA) receptor alpha (RAR alpha) and RAR gamma steady-state mRNA levels remained relatively constant over time after the addition of RA to F9 teratocarcinoma stem cells. In contrast, the steady-state RAR beta mRNA level started to increase within 12 h after the addition of RA and reached a 20-fold-higher level by 48 h. This RA-associated RAR beta mRNA increase was not prevented by protein synthesis inhibitors but was prevented by the addition of cyclic AMP analogs. In the presence of RA, cyclic AMP analogs also greatly reduced the RAR alpha and RAR gamma mRNA levels, even though cyclic AMP analogs alone did not alter these mRNA levels. The addition of either RA or RA plus cyclic AMP analogs did not result in changes in the three RAR mRNA half-lives. These results suggest that agents which elevate the internal cyclic AMP concentration may also affect the cellular response to RA by altering the expression of the RARs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.