ArticleMolecular and cellular biology1990
E1a transactivation of human HSP70 gene promoter substitution mutants is independent of the composition of upstream and TATA elements.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Activation of CREB/ATF sites by polyomavirus large T antigen.Journal of virology · 2005Article
- Expression levels of heat shock factors are not functionally coupled to the rate of expression of heat shock genes.Molecular biology reports · 1998Article
- Transcriptional transactivation of parvovirus B19 promoters in nonpermissive human cells by adenovirus type 2.Journal of virology · 1995Article
- Induction of transcription by a viral regulatory protein depends on the relative strengths of functional TATA boxes.Molecular and cellular biology · 1995Article
- Transcription stimulation of the adenovirus type 12 E1a gene in vitro by the 266-amino-acid E1A protein.Journal of virology · 1994Article
- Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription.Molecular and cellular biology · 1994Article
- Modulation of transcriptional activation of the proliferating cell nuclear antigen promoter by the adenovirus E1A 243-residue oncoprotein depends on proximal activators.Molecular and cellular biology · 1994Article
- Efficient transcriptional activation of many simple modular promoters by simian virus 40 large T antigen.Journal of virology · 1993Article
- Transcriptional activation by simian virus 40 large T antigen: requirements for simple promoter structures containing either TATA or initiator elements with variable upstream factor binding sites.Journal of virology · 1993Article
- Article
- A complex promoter element mediates transactivation of the human proliferating cell nuclear antigen promoter by the 243-residue adenovirus E1A oncoprotein.Molecular and cellular biology · 1993Article
- Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.Molecular and cellular biology · 1992Article
- trans-dominant mutants of E1A provide genetic evidence that the zinc finger of the trans-activating domain binds a transcription factor.Molecular and cellular biology · 1991Article
- Role of E2F transcription factor in E1A-mediated trans activation of cellular genes.Journal of virology · 1991Article
- Surprising features of transcriptional regulation of heat shock genes.Gene expression · 1991Review
- Regulation of heat shock factor in Schizosaccharomyces pombe more closely resembles regulation in mammals than in Saccharomyces cerevisiae.Molecular and cellular biology · 1991Article
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2 authors.
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Abstract
We have analyzed 41 deletion, linker scan, and substitution mutants of the human HSP70 gene promoter for activation by the adenovirus E1a region. No natural element of the HSP70 gene promoter was required for activation. To investigate specific interactions between E1a and transcription factors, a set of 24 promoters containing all possible combinations of eight different upstream or TATA motifs was investigated for E1a stimulation. E1a transactivated the promoter regardless of the particular TATA motif present. Furthermore, there was no dramatic correlation between any upstream motif and activation by E1a. These data suggest that E1a does not stimulate transcription via an interaction with any specific transcription factor but instead suggest that E1a interacts via the general transcription machinery.
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