ArticleMobile DNA2011
Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons.
Article in Mobile DNA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 124 citations in OpenAlex.
- Role of PsrA in physiology and virulence regulation inJournal of bacteriology · 2026Review
- Adaptative and ancient co-evolution of integrons withMicrobial genomics · 2025Article
- Integrons: the hidden architects of bacterial adaptation, evolution, and the challenges of antimicrobial resistance.Antonie van Leeuwenhoek · 2025Review
- The fitness connection of antibiotic resistance.Frontiers in microbiology · 2025Article
- Global genomic epidemiology ofMicrobial genomics · 2024Article
- Functional enrichment of integrons: Facilitators of antimicrobial resistance and niche adaptation.iScience · 2023Article
- A Class 4-like Chromosomal Integron Found inMicroorganisms · 2023Article
- Identification of integrons and gene cassette-associated recombination sites in bacteriophage genomes.Frontiers in microbiology · 2023Article
- Protozoal food vacuoles enhance transformation in Vibrio cholerae through SOS-regulated DNA integration.The ISME journal · 2022Article
- Activation of class 1 integron integrase is promoted in the intestinal environment.PLoS genetics · 2022Article
- Unbridled Integrons: A Matter of Host Factors.Cells · 2022Review
- Methods for the targeted sequencing and analysis of integrons and their gene cassettes from complex microbial communities.Microbial genomics · 2022Article
- Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation.Microorganisms · 2022Review
- Biochar and Manure Applications Differentially Altered the Class 1 Integrons, Antimicrobial Resistance, and Gene Cassettes Diversity in Paddy Soils.Frontiers in microbiology · 2022Article
- Non-canonical LexA proteins regulate the SOS response in the Bacteroidetes.Nucleic acids research · 2021Article
- Dynamics of integron structures across a wastewater network - Implications to resistance gene transfer.Water research · 2021Article
- The Natural History of Integrons.Microorganisms · 2021Review
- Metagenomic strategies identify diverse integron-integrase and antibiotic resistance genes in the Antarctic environment.MicrobiologyOpen · 2021Article
- Predicting the taxonomic and environmental sources of integron gene cassettes using structural and sequence homology of attC sites.Communications biology · 2021Article
- Cassette recruitment in the chromosomal Integron of Vibrio cholerae.Nucleic acids research · 2021Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntegrons are found in hundreds of environmental bacterial species, but are mainly known as the agents responsible for the capture and spread of antibiotic-resistance determinants between Gram-negative pathogens. The SOS response is a regulatory network under control of the repressor protein LexA targeted at addressing DNA damage, thus promoting genetic variation in times of stress. We recently reported a direct link between the SOS response and the expression of integron integrases in Vibrio cholerae and a plasmid-borne class 1 mobile integron. SOS regulation enhances cassette swapping and capture in stressful conditions, while freezing the integron in steady environments. We conducted a systematic study of available integron integrase promoter sequences to analyze the extent of this relationship across the Bacteria domain.
resultsOur results showed that LexA controls the expression of a large fraction of integron integrases by binding to Escherichia coli-like LexA binding sites. In addition, the results provide experimental validation of LexA control of the integrase gene for another Vibrio chromosomal integron and for a multiresistance plasmid harboring two integrons. There was a significant correlation between lack of LexA control and predicted inactivation of integrase genes, even though experimental evidence also indicates that LexA regulation may be lost to enhance expression of integron cassettes.
conclusionsAncestral-state reconstruction on an integron integrase phylogeny led us to conclude that the ancestral integron was already regulated by LexA. The data also indicated that SOS regulation has been actively preserved in mobile integrons and large chromosomal integrons, suggesting that unregulated integrase activity is selected against. Nonetheless, additional adaptations have probably arisen to cope with unregulated integrase activity. Identifying them may be fundamental in deciphering the uneven distribution of integrons in the Bacteria domain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.