ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2011
Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01518777 (Reducing Radioisotope Dose in Regadenoson SPECT Myocardial Perfusion Imaging), which is not on this map. Cited by 66 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Radioisotope Dose in Regadenoson SPECT Myocardial Perfusion Imaging: Comparison of Half-Dose Scans Using a Novel Solid-State-Detector Dedicated Cardiac Camera to Full Dose Scans Acquired On Standard Equipment
Who cites it
66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Diagnostic performance of myocardial perfusion imaging with conventional and CZT single-photon emission computed tomography in detecting coronary artery disease: A meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Pooled it
- Update of the Brazilian Guideline on Nuclear Cardiology - 2020.Arquivos brasileiros de cardiologia · 2020Guideline
- Pooled it
- Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols.European journal of nuclear medicine and molecular imaging · 2013Trial
- Evaluation of ischaemia in obese patients: feasibility and accuracy of a low-dose protocol with a cadmium-zinc telluride camera.European journal of nuclear medicine and molecular imaging · 2012Trial
- High diagnostic accuracy of low-dose gated-SPECT with solid-state ultrafast detectors: preliminary clinical results.European journal of nuclear medicine and molecular imaging · 2012Trial
- Myocardial Involvement in Systemic Sclerosis: A State-of-the-Art Review of Multimodality Cardiovascular Imaging.Diagnostics (Basel, Switzerland) · 2026Review
- Development and clinical application of biological dosimetry technology: insights from the HICARE/IAEA 2025 international training course.Journal of radiation research · 2026Article
- Strategic Objectives of Nanotechnology-Driven Repurposing in Radiopharmacy-Implications for Radiopharmaceutical Repurposing (Beyond Oncology).Pharmaceutics · 2025Review
- Recent Progress in Myocardial Perfusion Imaging Techniques.Nuclear medicine and molecular imaging · 2024Review
- Deep learning-based multi-frequency denoising for myocardial perfusion SPECT.EJNMMI physics · 2024Article
- Same same but different: dopamine transporter SPECT on scanners with CZT vs. NaI detectors.EJNMMI research · 2023Article
- Deep learning prediction of quantitative coronary angiography values using myocardial perfusion images with a CZT camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- CZT camera systems may provide better risk stratification for low-risk patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Balancing risks and rewards in assessing pediatric heart disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- First comparison of performances between the new whole-body cadmium-zinc-telluride SPECT-CT camera and a dedicated cardiac CZT camera for myocardial perfusion imaging: Analysis of phantom and patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Simultaneous dual isotopeJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Ultra-low-dose computed tomography for attenuation correction of cadmium-zinc-telluride single photon emission computed tomography myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Real-time gated-SPECT myocardial perfusion imaging with CZT detectors: A promising tool for monitoring left ventricular function.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Current outlook on radionuclide delivery systems: from design consideration to translation into clinics.Journal of nanobiotechnology · 2019Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn light of recent focus on diagnostic imaging, cardiac SPECT imaging needs to become a shorter test with lower radiation exposure to patients. Recently introduced Cadmium Zinc Telluride (CZT) cameras have the potential to achieve both goals.
methodsDuring a 2-month period patients presenting for a Tc-99m sestamibi SPECT MPI study were imaged using a CZT camera using a low-dose rest-stress protocol (5 mCi rest and 15 mCi stress doses). Patients ≥250 lbs or a BMI ≥35 kg/m(2) were excluded. Rest images were processed at 5- and 8-minute acquisition times and stress images at 3- and 5-minute acquisition times. A subset of patients had stress imaging performed using both conventional and CZT SPECT cameras. Image acquisition times and SPECT camera images were compared based on total counts, count rate, image quality, and summed rest and stress scores. Twelve month clinical follow-up was also obtained.
results131 patients underwent the study protocol (age 64.9 ± 9.8 years, 54.2% male). There was no significant difference in image quality and mean summed scores between 5- and 8-minute rest images and between 3- and 5-minute stress images. When compared to a conventional SPECT camera in 27 patients, total rest and stress perfusion deficits and calculated LVEF were similar (r = 0.94 and 0.96, respectively). At 12 months there was a benign prognosis in patients with normal perfusion. The effective dose was 5.8 mSv for this protocol which is 49.2% less than conventional Tc-99m studies and 75.7% less than conventional Tl-201/Tc-99m dual isotope studies.
conclusionsNew SPECT camera technology with low isotope dose significantly reduces ionizing radiation exposure and imaging times compared to traditional protocols while maintaining image quality and diagnostic accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.