ReviewProtein & cell2011
Silencing suppressors: viral weapons for countering host cell defenses.
Review in Protein & cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- SFTSV NSs protein is a tick antiviral RNAi response suppressor.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Trans-acting regulators of ribonuclease activity.Journal of microbiology (Seoul, Korea) · 2021Review
- Light-Engineering Technology for Enhancing Plant Disease Resistance.Frontiers in plant science · 2021Review
- s8ORF2 protein of infectious salmon anaemia virus is a RNA-silencing suppressor and interacts with Salmon salar Mov10 (SsMov10) of the host RNAi machinery.Virus genes · 2018Article
- RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-κB-IL-8 axis.Cell death & disease · 2017Article
- Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells.Chinese journal of cancer · 2017Article
- Article
- Arbovirus-mosquito interactions: RNAi pathway.Current opinion in virology · 2015Review
- Identification and validation of sugarcane streak mosaic virus-encoded microRNAs and their targets in sugarcane.Plant cell reports · 2014Article
- Supervised learning classification models for prediction of plant virus encoded RNA silencing suppressors.PloS one · 2014Article
- The HIV Nef protein modulates cellular and exosomal miRNA profiles in human monocytic cells.Journal of extracellular vesicles · 2014Article
- Article
- Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor.Journal of virology · 2013Article
- Gene silencing in tick cell lines using small interfering or long double-stranded RNA.Experimental & applied acarology · 2013Article
- Transgene-mediated suppression of the RNA interference pathway in Aedes aegypti interferes with gene silencing and enhances Sindbis virus and dengue virus type 2 replication.Insect molecular biology · 2013Article
- Organ-specific alterations in tobacco transcriptome caused by the PVX-derived P25 silencing suppressor transgene.BMC plant biology · 2013Article
- The HIV-1 Nef protein binds argonaute-2 and functions as a viral suppressor of RNA interference.PloS one · 2013Article
- Article
- Did silencing suppression counter-defensive strategy contribute to origin and evolution of the triple gene block coding for plant virus movement proteins?Frontiers in plant science · 2012Article
- Replication competent HIV-1 viruses that express intragenomic microRNA reveal discrete RNA-interference mechanisms that affect viral replication.Cell & bioscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA silencing is a conserved eukaryotic pathway involved in the suppression of gene expression via sequence-specific interactions that are mediated by 21-23 nt RNA molecules. During infection, RNAi can act as an innate immune system to defend against viruses. As a counter-defensive strategy, silencing suppressors are encoded by viruses to inhibit various stages of the silencing process. These suppressors are diverse in sequence and structure and act via different mechanisms. In this review, we discuss whether RNAi is a defensive strategy in mammalian host cells and whether silencing suppressors can be encoded by mammalian viruses. We also review the modes of action proposed for some silencing suppressors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.