Trial reportThe journal of nutrition, health & aging2011
Nutritional approach for inhibiting bone resorption in institutionalized elderly women with vitamin D insufficiency and high prevalence of fracture.
Trial report in The journal of nutrition, health & aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Vitamin D deficiency in nursing home residents: a systematic review.Nutrition reviews · 2023Pooled it
- Effects of Dietary or Supplementary Micronutrients on Sex Hormones and IGF-1 in Middle and Older Age: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Supportive interventions for enhancing dietary intake in malnourished or nutritionally at-risk adults.The Cochrane database of systematic reviews · 2016Pooled it
- Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- Effect of Vitamin D-Enriched Gouda-Type Cheese Consumption on Biochemical Markers of Bone Metabolism in Postmenopausal Women in Greece.Nutrients · 2021Trial
- Reduced-fat Gouda-type cheese enriched with vitamin DEuropean journal of nutrition · 2017Trial
- Fermented Dairy Products, Musculoskeletal and Mental Health in Older Adults: is There Evidence to Support Benefits that go Beyond Those of Non-Fermented Dairy Products?Calcified tissue international · 2024Review
- Vitamin D Deficiency Is Frequent in Patients with Rapidly Destructive Osteoarthritis-Data from a Single-Center Analysis.Journal of clinical medicine · 2024Article
- The effect of cheese intake on osteoarthritis: a Mendelian randomization study.Archives of medical science : AMS · 2024Article
- Mineral Supplements in Ageing.Sub-cellular biochemistry · 2024Review
- Fortification of Staple Foods for Household Use with Vitamin D: An Overview of Systematic Reviews.Nutrients · 2023Review
- 25-Hydroxyvitamin D as a Biomarker of Vitamin D Status and Its Modeling to Inform Strategies for Prevention of Vitamin D Deficiency within the Population.Advances in nutrition (Bethesda, Md.) · 2017Review
- Cheese as Functional Food: The Example of Parmigiano Reggiano and Grana Padano.Food technology and biotechnology · 2017Review
- Food fortification for bone health in adulthood: a scoping review.European journal of clinical nutrition · 2016Article
- Biochemical markers for assessment of calcium economy and bone metabolism: application in clinical trials from pharmaceutical agents to nutritional products.Nutrition research reviews · 2014Review
- Increasing dietary phosphorus intake from food additives: potential for negative impact on bone health.Advances in nutrition (Bethesda, Md.) · 2014Review
- Dairy in adulthood: from foods to nutrient interactions on bone and skeletal muscle health.Journal of the American College of Nutrition · 2013Review
- The role of diet in osteoporosis prevention and management.Current osteoporosis reports · 2012Review
- Parmigiano Reggiano cheese and bone health.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNutritional approach to the deterioration of bone integrity and increased fracture risk appears to be particularly appropriate in elderly women living in nursing homes.
objectiveTo investigate the beneficial effect of the consumption of soft plain cheese on bone resorption markers in institutionalized elderly women.
designProspective, randomized crossover controlled study.
settingSix French nursing homes or other institutions for elderly.
participantsInstitutionalized women ≥ 65 years old with low vitamin D status and calcium intake below 700 mg/day.
interventionConsumption of soft plain cheese made of semi-skimmed milk which was fortified by both vitamin D3 (+1.25 µg/100g) and milk extracted Ca, thus achieving a total Ca content of 151 mg/100g as compared to about 118 mg/100g for standard fresh cheese. Two servings were taken every day during the 6 weeks that preceded or followed a period of 6 weeks without soft plain cheese consumption. MEASUREMENTS: The primary end point was the change in serum carboxy terminal cross-linked telopeptide of type I collagen (CTX) selected as a marker of bone resorption.
results29 women aged 73-94 yr were selected, 21 of them with mean age 87.2±6.1 years remained compliant. The intervention increased calcium and protein intakes by 51% (904±228 vs. 599±122 mg/d) and 33 % (74.2±17.1 vs. 55.6±12.7 g/d, mean±SD), respectively. The dietary intervention was associated with a statistically significant increase in serum levels of both 25OHD and IGF-I, while those of [corrected] CTX and TRAP5b were significantly reduced. Compliance was 93,4 %. The daily consumption of two servings of soft plain cheese was well accepted in terms of tastiness and appetite suited portion size.
conclusionThis randomized crossover controlled trial demonstrates that in elderly women living in nursing homes, the consumption of soft plain cheese increasing the supply of vitamin D, calcium and proteins, could reduce bone resorption and thereby reduce the risk of incidental fragility fractures in the long term.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.