ArticleMolecular vision2011
Pre-corneal tear film thickness in humans measured with a novel technique.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Ultrahigh-resolution anterior segment optical coherence tomography for analysis of corneal microarchitecture during wound healing.Acta ophthalmologica · 2019Trial
- The role of corneal epithelial thickness parameters with different degrees of keratoconus in the diagnosis of keratoconus.Molecular vision · 2026Article
- Identification of tear lipid biomarkers in women with dry eye disease and the impact of intense pulsed light therapy: a case-control study.BMC ophthalmology · 2025Observational
- Corneal Epithelial Thickness Changes After Topical Treatment of Dry Eye Disease in Primary Sjögren Syndrome.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Corneal Epithelial Mapping Characteristics in Normal Eyes Using Anterior Segment Spectral Domain Optical Coherence Tomography.Translational vision science & technology · 2022Article
- Corneal Epithelium Asymmetry in Children With Atopy: The Effect of Hand Dominance.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Human meibum and tear film derived (O-acyl)-omega-hydroxy fatty acids in meibomian gland dysfunction.The ocular surface · 2021Article
- A Review of Structural and Biomechanical Changes in the Cornea in Aging, Disease, and Photochemical Crosslinking.Frontiers in bioengineering and biotechnology · 2019Review
- Comparison of Collection Methods for the Measure of Human Meibum and Tear Film-Derived Lipids Using Mass Spectrometry.Current eye research · 2018Article
- Photoactivatable fluorescent probes reveal heterogeneous nanoparticle permeation through biological gels at multiple scales.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Age-related differences in corneal epithelial thickness measurements with anterior segment optical coherence tomography.Japanese journal of ophthalmology · 2016Article
- Corneal Epithelium Thickness Profile in 614 Normal Chinese Children Aged 7-15 Years Old.Scientific reports · 2016Article
- Comparison of Corneal Epithelial Thickness Measurement Between Fourier-Domain OCT and Very High-Frequency Digital Ultrasound.Journal of refractive surgery (Thorofare, N.J. : 1995) · 2015Article
- THz and mm-Wave Sensing of Corneal Tissue Water Content: Electromagnetic Modeling and Analysis.IEEE transactions on terahertz science and technology · 2015Article
- Tear film measurement by optical reflectometry technique.Journal of biomedical optics · 2014Article
- Novel strategies for anterior segment ocular drug delivery.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2013Review
- Corneal epithelial thickness mapping by Fourier-domain optical coherence tomography in normal and keratoconic eyes.Ophthalmology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe purpose of this work was to gather preliminary data in normals and dry eye subjects, using a new, non-invasive imaging platform to measure the thickness of pre-corneal tear film.
methodsHuman subjects were screened for dry eye and classified as dry or normal. Tear film thickness over the inferior paracentral cornea was measured using laser illumination and a complementary metal-oxide-semiconductor (CMOS) camera. A previously developed mathematical model was used to calculate the thickness of the tear film by applying the principle of spatial auto-correlation function (ACF).
resultsMean tear film thickness values (±SD) were 3.05 μm (0.20) and 2.48 μm (0.32) on the initial visit for normals (n=18) and dry eye subjects (n=22), respectively, and were significantly different (p<0.001, 2-sample t-test). Repeatability was good between visit 1 and 2 for normals (intraclass correlation coefficient [ICC]=0.935) and dry eye subjects (ICC=0.950). Tear film thickness increased above baseline for the dry eye subjects following viscous drop instillation and remained significantly elevated for up to approximately 32 min (n=20; p<0.05 until 32 min; general linear mixed model and Dunnett's tests).
conclusionsThis technique for imaging the ocular surface appears to provide tear thickness values in agreement with other non-invasive methods. Moreover, the technique can differentiate between normal and dry eye patient types.
Indexed as
Identifiers
21527997PMC3081798W2116489383What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.