ReviewCell cycle (Georgetown, Tex.)2011
FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair.
Review in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Roles of Human Endogenous Retroviruses and Endogenous Virus-Like Elements in Cancer Development and Innate Immunity.Biomolecules · 2023Review
- SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.Nucleic acids research · 2019Article
- Referral frequency, attrition rate, and outcomes of germline testing in patients with pancreatic adenocarcinoma.Familial cancer · 2019Article
- The role of SLX4 and its associated nucleases in DNA interstrand crosslink repair.Nucleic acids research · 2019Article
- Article
- Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex.Nucleic acids research · 2016Article
- Cooperativity of the SUMO and Ubiquitin Pathways in Genome Stability.Biomolecules · 2016Review
- Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING.Journal of virology · 2016Article
- The Simple Chordate Ciona intestinalis Has a Reduced Complement of Genes Associated with Fanconi Anemia.Evolutionary bioinformatics online · 2016Article
- Physical interaction between SLX4 (FANCP) and XPF (FANCQ) proteins and biological consequences of interaction-defective missense mutations.DNA repair · 2015Article
- Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy.Molecules and cells · 2015Review
- Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.Molecular cancer therapeutics · 2015Article
- Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease.Cell reports · 2015Article
- Review
- Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2.PLoS biology · 2014Article
- Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Article
- The genetic and biochemical basis of FANCD2 monoubiquitination.Molecular cell · 2014Article
- Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA.Nucleic acids research · 2014Article
- RAD51C--a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC).Oral oncology · 2014Article
- From arrest to escape: HIV-1 Vpr cuts a deal.Cell host & microbe · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Fanconi anemia (FA) is a rare genetic disease characterized by congenital abnormalities, bone marrow failure and heightened cancer susceptibility. The FA proteins are known to function in the cellular defense against DNA interstrand crosslinks (ICLs), a process that remains poorly understood. A recent spate of discoveries has led to the identification of one new FA gene, FANCP/SLX4, and two strong candidate FA genes, FAN1 and RAD51C. In this perspective we describe the discovery of FANCP/SLX4 and discuss how these new findings collectively refine our understanding of DNA ICL repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.