ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Vagal-dependent nonlinear variability in the respiratory pattern of anesthetized, spontaneously breathing rats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of environment light during sleep on autonomic functions of heart rate and breathing.Sleep & breathing = Schlaf & Atmung · 2014Trial
- Peritoneal sepsis caused by Escherichia coli triggers brainstem inflammation and alters the function of sympatho-respiratory control circuits.Journal of neuroinflammation · 2024Article
- Repeated seizures lead to progressive ventilatory dysfunction in SSJournal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Cannabinoid Receptor mRNA Expression in Central and Peripheral Tissues in a Rodent Model of Peritonitis.Cannabis and cannabinoid research · 2023Article
- Dynamics of ventilatory pattern variability and Cardioventilatory Coupling during systemic inflammation in rats.Frontiers in network physiology · 2023Article
- Temporal variations in the pattern of breathing: techniques, sources, and applications to translational sciences.The journal of physiological sciences : JPS · 2022Review
- Automated evaluation of respiratory signals to provide insight into respiratory drive.Respiratory physiology & neurobiology · 2022Article
- Article
- Acute lung injury in neonatal rats causes postsynaptic depression in nucleus tractus solitarii second-order neurons.Respiratory physiology & neurobiology · 2019Article
- Ventilatory pattern variability as a biometric for severity of acute lung injury in rats.Respiratory physiology & neurobiology · 2019Article
- Mid-cervical spinal cord contusion causes robust deficits in respiratory parameters and pattern variability.Experimental neurology · 2018Article
- A Subregion of the Parabrachial Nucleus Partially Mediates Respiratory Rate Depression from Intravenous Remifentanil in Young and Adult Rabbits.Anesthesiology · 2017Article
- Kölliker-Fuse nuclei regulate respiratory rhythm variability via a gain-control mechanism.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Effects of ion channel noise on neural circuits: an application to the respiratory pattern generator to investigate breathing variability.Journal of neurophysiology · 2017Article
- Ventilatory pattern and energy expenditure are altered in cystic fibrosis mice.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2013Article
- Breathing irregularity during wakefulness associates with CPAP acceptance in sleep apnea.Sleep & breathing = Schlaf & Atmung · 2013Article
- Isoflurane and ketamine anesthesia have different effects on ventilatory pattern variability in rats.Respiratory physiology & neurobiology · 2013Article
- Decreased Hering-Breuer input-output entrainment in a mouse model of Rett syndrome.Frontiers in neural circuits · 2013Article
- Pontine mechanisms of respiratory control.Comprehensive Physiology · 2012Review
- Linking Inflammation, Cardiorespiratory Variability, and Neural Control in Acute Inflammation via Computational Modeling.Frontiers in physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Physiological rhythms, including respiration, exhibit endogenous variability associated with health, and deviations from this are associated with disease. Specific changes in the linear and nonlinear sources of breathing variability have not been investigated. In this study, we used information theory-based techniques, combined with surrogate data testing, to quantify and characterize the vagal-dependent nonlinear pattern variability in urethane-anesthetized, spontaneously breathing adult rats. Surrogate data sets preserved the amplitude distribution and linear correlations of the original data set, but nonlinear correlation structure in the data was removed. Differences in mutual information and sample entropy between original and surrogate data sets indicated the presence of deterministic nonlinear or stochastic non-Gaussian variability. With vagi intact (n = 11), the respiratory cycle exhibited significant nonlinear behavior in templates of points separated by time delays ranging from one sample to one cycle length. After vagotomy (n = 6), even though nonlinear variability was reduced significantly, nonlinear properties were still evident at various time delays. Nonlinear deterministic variability did not change further after subsequent bilateral microinjection of MK-801, an N-methyl-D-aspartate receptor antagonist, in the Kölliker-Fuse nuclei. Reversing the sequence (n = 5), blocking N-methyl-D-aspartate receptors bilaterally in the dorsolateral pons significantly decreased nonlinear variability in the respiratory pattern, even with the vagi intact, and subsequent vagotomy did not change nonlinear variability. Thus both vagal and dorsolateral pontine influences contribute to nonlinear respiratory pattern variability. Furthermore, breathing dynamics of the intact system are mutually dependent on vagal and pontine sources of nonlinear complexity. Understanding the structure and modulation of variability provides insight into disease effects on respiratory patterning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.