Evidence map›Paper›PMID 21527646›Full record

ArticleClinical journal of the American Society of Nephrology : CJASN2011

Quality-of-life and mortality in hemodialysis patients: roles of race and nutritional status.

Usama Feroze, Nazanin Noori, Csaba P Kovesdy, Miklos Z Molnar, David J Martin, Astrid Reina-Patton, Debbie Benner, Rachelle Bross, Keith C Norris, Joel D Kopple and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Clinical journal of the American Society of Nephrology : CJASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01415570 (Malnutrition, Diet and Racial Disparities in Chronic Kidney Disease), which is not on this map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01415570 unknown statusnot on this map

Malnutrition, Diet and Racial Disparities in Chronic Kidney Disease (CKD) - A Prospective Data Collection Study

TypeobservationalSponsorLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterRan2011 to 2016Enrolled1,050ConditionsChronic Kidney Disease (CKD), End-Stage Renal Disease (ESRD)
3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Article
  6. Assessment of nutritional status and associated factors among hemodialysis patients in Isfahan, Iran.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Article
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  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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  14. Article
  15. Article
  16. Observational
  17. Health-related quality of life associated with risk of death in Brazilian dialysis patients: an eight-year cohort.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Observational
  18. Examining the relationship between nutrition, quality of life, and depression in hemodialysis patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Usama FerozeHarold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, C1-Annex, Torrance, CA 90502, USA.
Nazanin Noori
Csaba P Kovesdy
Miklos Z Molnar
David J Martin
Astrid Reina-Patton
Debbie Benner
Rachelle Bross
Keith C Norris
Joel D Kopple
Kamyar Kalantar-Zadeh

Funding

ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
TRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI CUNNINGHAM, WILLIAM EMERY, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5M
VITAMIN D STIMULATES CARDIAC DIFFERENTIATIONU54RR026138 · NCRR · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI NORRIS, KEITH C · 2009 to 2011
$14.0M
Nutritional/Inflammatory Evaluation of Dialysis PatientsK23DK061162 · NIDDK · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI KALANTAR-ZADEH, KAMYAR · 2001 to 2005
$797k
Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis PatientsR21DK078012 · NIDDK · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI KALANTAR-ZADEH, KAMYAR · 2007 to 2008
$380k
NCRR NIH HHS M01 RR000425NCRR NIH HHS M01-RR00425NCRR NIH HHS RR026138NCRR NIH HHS U54 RR026138NIDDK NIH HHS K23 DK061162NIDDK NIH HHS K23 DK61162NIDDK NIH HHS R21 DK078012NIDDK NIH HHS R21DK078012NIMHD NIH HHS MD00182NIMHD NIH HHS P20 MD000182
6 · The paper itself

Abstract

BACKGROUND AND

objectivesMaintenance hemodialysis (MHD) patients often have protein-energy wasting, poor health-related quality of life (QoL), and high premature death rates, whereas African-American MHD patients have greater survival than non-African-American patients. We hypothesized that poor QoL scores and their nutritional correlates have a bearing on racial survival disparities of MHD patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We examined associations between baseline self-administered SF36 questionnaire-derived QoL scores with nutritional markers by multivariate linear regression and with survival by Cox models and cubic splines in the 6-year cohort of 705 MHD patients, including 223 African Americans.

resultsWorse SF36 mental and physical health scores were associated with lower serum albumin and creatinine levels but higher total body fat percentage. Spline analyses confirmed mortality predictability of worse QoL, with an almost strictly linear association for mental health score in African Americans, although the race-QoL interaction was not statistically significant. In fully adjusted analyses, the mental health score showed a more robust and linear association with mortality than the physical health score in all MHD patients and both races: death hazard ratios for (95% confidence interval) each 10 unit lower mental health score were 1.12 (1.05-1.19) and 1.10 (1.03-1.18) for all and African American patients, respectively.

conclusionsMHD patients with higher percentage body fat or lower serum albumin or creatinine concentration perceive a poorer QoL. Poor mental health in all and poor physical health in non-African American patients correlate with mortality. Improving QoL by interventions that can improve the nutritional status without increasing body fat warrants clinical trials.

Indexed as

Nutritional StatusQuality of LifeAdipose TissueAdultAgedBlack or African AmericanCohort StudiesCreatinineFemaleHealth StatusHumansKidney Failure, ChronicMaleMiddle AgedProspective StudiesRenal DialysisCreatinineSerum Albumin

Identifiers

PMID21527646
PMCPMC3087777

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.