ArticleThe Journal of biological chemistry2011
N-formylkynurenine as a marker of high light stress in photosynthesis.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 73 citations in OpenAlex.
- Trp521 oxidation affects FtsH2 stability and its role in PSII repair.The New phytologist · 2026Article
- Singlet Oxygen in Plants: Mechanistic Insights into Production, Oxidative Damage, and Stress-Response Signaling.Antioxidants (Basel, Switzerland) · 2026Review
- Photocatalytic oxidation of tyrosine using colloidal CdS particles under visible light irradiation.Scientific reports · 2025Article
- Protein phosphorylation and oxidative protein modification promote plant photosystem II disassembly for repair.Plant communications · 2025Article
- Fluorescence of Intrinsic Milk Chromophores as a Novel Verification Method of UV-C Treatment of Milk.Foods (Basel, Switzerland) · 2024Article
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- Vermilion and cinnabar are involved in ommochrome pigment biosynthesis in eyes but not wings of Bicyclus anynana butterflies.Scientific reports · 2023Article
- Reactive oxygen species in photosystem II: relevance for oxidative signaling.Photosynthesis research · 2022Review
- Metabolomic Insights of the Effects of Bacterial Algicide IRI-160AA on DinoflagellateMetabolites · 2022Article
- Chloroplast ROS and stress signaling.Plant communications · 2022Review
- Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques.Pharmaceutics · 2021Review
- Current Understanding of Temperature Stress-Responsive Chloroplast FtsH Metalloproteases.International journal of molecular sciences · 2021Review
- Singlet-Oxygen-Induced Phospholipase AChemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- The Different Colors of mAbs in Solution.Antibodies (Basel, Switzerland) · 2021Review
- Photo-Degradation of Therapeutic Proteins: Mechanistic Aspects.Pharmaceutical research · 2020Review
- Impaired PSII Proteostasis Promotes Retrograde Signaling via Salicylic Acid.Plant physiology · 2019Article
- Oxidative post-translational modification of EXECUTER1 is required for singlet oxygen sensing in plastids.Nature communications · 2019Article
- ROS-Driven Oxidative Modification: Its Impact on Chloroplasts-Nucleus Communication.Frontiers in plant science · 2019Review
- FtsH Protease in the Thylakoid Membrane: Physiological Functions and the Regulation of Protease Activity.Frontiers in plant science · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photosystem II (PSII) is the membrane protein complex that catalyzes the photo-induced oxidation of water at a manganese-calcium active site. Light-dependent damage and repair occur in PSII under conditions of high light stress. The core reaction center complex is composed of the D1, D2, CP43, and CP47 intrinsic polypeptides. In this study, a new chromophore formed from the oxidative post-translational modification of tryptophan is identified in the CP43 subunit. Tandem mass spectrometry peptide sequencing is consistent with the oxidation of the CP43 tryptophan side chain, Trp-365, to produce N-formylkynurenine (NFK). Characterization with ultraviolet visible absorption and ultraviolet resonance Raman spectroscopy supports this assignment. An optical assay suggests that the yield of NFK increases 2-fold (2.2 ± 0.5) under high light illumination. A concomitant 2.4 ± 0.5-fold decrease is observed in the steady-state rate of oxygen evolution under the high light conditions. NFK is the product formed from reaction of tryptophan with singlet oxygen, which can be produced under high light stress in PSII. Reactive oxygen species reactions lead to oxidative damage of the reaction center, D1 protein turnover, and inhibition of electron transfer. Our results are consistent with a role for the CP43 NFK modification in photoinhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.