ArticleMicrobiology (Reading, England)2011
Interaction of Bacteroides fragilis and Bacteroides thetaiotaomicron with the kallikrein-kinin system.
Article in Microbiology (Reading, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- The Role of Lactiplantibacillus plantarum CGMCC9513 in Alleviating Colitis by Synergistic Enhancement of the Intestinal Barrier Through Modulating Gut Microbiota and Activating the Aryl Hydrocarbon Receptor.Probiotics and antimicrobial proteins · 2026Article
- Bacterial infection and activation of the contact pathway of coagulation.Blood vessels, thrombosis & hemostasis · 2025Review
- Bacteroides maternus sp. nov., a novel species isolated from human faeces.Scientific reports · 2025Article
- The bradykinin-forming cascade in anaphylaxis and ACE-inhibitor induced angioedema/airway obstruction.Frontiers in allergy · 2024Review
- Integrated 'omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- IRW (Ile-Arg-Trp) Alleviates DSS-Induced Intestinal Injury by Remodeling Gut Microbiota and Regulating Fecal SCFA Levels.Nutrients · 2023Article
- Throat microbiota alterations in patients with hereditary angioedema.The World Allergy Organization journal · 2022Article
- Serum bridging molecules drive candidal invasion of human but not mouse endothelial cells.PLoS pathogens · 2022Article
- Article
- Introduction to host microbiome symbiosis in health and disease.Mucosal immunology · 2021Review
- Intestinal Metagenomes and Metabolomes in Healthy Young Males: Inactivity and Hypoxia Generated Negative Physiological Symptoms Precede Microbial Dysbiosis.Frontiers in physiology · 2018Article
- Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion.Infection and immunity · 2016Article
- Bifidobacterium bifidum PRL2010 modulates the host innate immune response.Applied and environmental microbiology · 2014Article
- The role of coagulation/fibrinolysis during Streptococcus pyogenes infection.Frontiers in cellular and infection microbiology · 2014Review
- Interaction between Paracoccidioides brasiliensis conidia and the coagulation system: involvement of fibrinogen.Memorias do Instituto Oswaldo Cruz · 2013Article
- Large-scale chromatin immunoprecipitation with promoter sequence microarray analysis of the interaction of the NSs protein of Rift Valley fever virus with regulatory DNA regions of the host genome.Journal of virology · 2012Article
- Streptococcal surface proteins activate the contact system and control its antibacterial activity.The Journal of biological chemistry · 2012Article
- GutGut microbesReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many bacterial pathogens interfere with the contact system (kallikrein-kinin system) in human plasma. Activation of this system has two consequences: cleavage of high-molecular-mass kininogen (HK) resulting in release of the potent proinflammatory peptide bradykinin, and initiation of the intrinsic pathway of coagulation. In this study, two species of the Gram-negative anaerobic commensal organism Bacteroides, namely Bacteroides fragilis and Bacteroides thetaiotaomicron, were found to bind HK and fibrinogen, the major clotting protein, from human plasma as shown by immunoelectron microscopy and Western blot analysis. In addition, these Bacteroides species were capable of activating the contact system at its surface leading to a significant prolongation of the intrinsic coagulation time and also to the release of bradykinin. Members of the genus Bacteroides have been known to act as opportunistic pathogens outside the gut, with B. fragilis being the most common isolate from clinical infections, such as intra-abdominal abscesses and bacteraemia. The present results thus provide more insight into how Bacteroides species cause infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.