ArticleInvestigative ophthalmology & visual science2011
A prototype antifungal contact lens.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 103 citations in OpenAlex.
- Formulation-Driven Innovation in Antifungal Therapy: From Nanotechnology to AI-Assisted Design.International journal of nanomedicine · 2026Review
- From Vision Correction to Drug Delivery: Unraveling the Potential of Therapeutic Contact Lens.Current drug delivery · 2025Review
- Recent Advances in Diagnosis and Treatment Approaches in Fungal Keratitis: A Narrative Review.Microorganisms · 2024Review
- Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases.Drug delivery · 2023Review
- Drug-Eluting Sandwich Hydrogel Lenses Based on Microchamber Film Drug Encapsulation.ACS nanoscience Au · 2023Article
- Review of Potential Drug-Eluting Contact Lens Technologies.Materials (Basel, Switzerland) · 2023Review
- Cellulose Acetate Phthalate-Based pH-Responsive Cyclosporine A-Loaded Contact Lens for the Treatment of Dry Eye.International journal of molecular sciences · 2023Article
- Progress of polymer-based strategies in fungal disease management: Designed for different roles.Frontiers in cellular and infection microbiology · 2023Review
- Topical Sustained Delivery of Miltefosine Via Drug-Eluting Contact Lenses to Treat Acanthamoeba Keratitis.Pharmaceutics · 2022Article
- Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Update on diagnosis and management of refractory corneal infections.Indian journal of ophthalmology · 2022Review
- Targeting Ocular Drug Delivery: An Examination of Local Anatomy and Current Approaches.Bioengineering (Basel, Switzerland) · 2022Review
- Recent Perspectives in the Management of Fungal Keratitis.Journal of fungi (Basel, Switzerland) · 2021Review
- Drug delivery to the anterior segment of the eye: A review of current and future treatment strategies.International journal of pharmaceutics · 2021Review
- Soft Contact Lenses as Drug Delivery Systems: A Review.Molecules (Basel, Switzerland) · 2021Review
- Review
- Steroid-eluting contact lenses for corneal and intraocular inflammation.Acta biomaterialia · 2020Article
- Advances in chemistry and composition of soft materials for drug releasing contact lenses.RSC advances · 2020Review
- Bimatoprost Imprinted Silicone Contact Lens to Treat Glaucoma.AAPS PharmSciTech · 2020Article
- Innovative Development of Contact Lenses.Cornea · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeTo design a contact lens to treat and prevent fungal ocular infections.
methodsCurved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in phosphate-buffered saline at 37°C with continuous shaking. The contact lenses and their release media were tested in an antifungal assay against Candida albicans. Cross sections of the pre- and postrelease contact lenses were characterized by scanning electron microscopy and by Raman spectroscopy.
resultsEconazole-eluting contact lenses provided extended antifungal activity against Candida albicans fungi. Fungicidal activity varied in duration and effectiveness depending on the mass of the econazole-PLGA film encapsulated in the contact lens.
conclusionsAn econazole-eluting contact lens could be used as a treatment for fungal ocular infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.