ArticleInvestigative ophthalmology & visual science2011
An applet to estimate the IOP-induced stress and strain within the optic nerve head.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- Strain by virtual extensometers and video-imaging optical coherence tomography as a repeatable metric for IOP-Induced optic nerve head deformations.Experimental eye research · 2021Article
- Biomechanics of the optic nerve head and sclera in canine glaucoma: A brief review.Veterinary ophthalmology · 2021Review
- Role of radially aligned scleral collagen fibers in optic nerve head biomechanics.Experimental eye research · 2020Article
- Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics.Investigative ophthalmology & visual science · 2018Article
- Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult.Investigative ophthalmology & visual science · 2017Article
- What is a typical optic nerve head?Experimental eye research · 2016Article
- Effects of Peripapillary Scleral Stiffening on the Deformation of the Lamina Cribrosa.Investigative ophthalmology & visual science · 2016Article
- Use and Misuse of Laplace's Law in Ophthalmology.Investigative ophthalmology & visual science · 2016Review
- Application of Elliptic Fourier analysis to describe the lamina cribrosa shape with age and intraocular pressure.Experimental eye research · 2014Article
- A method to estimate biomechanics and mechanical properties of optic nerve head tissues from parameters measurable using optical coherence tomography.IEEE transactions on medical imaging · 2014Article
- Intraocular pressure, blood pressure, and retinal blood flow autoregulation: a mathematical model to clarify their relationship and clinical relevance.Investigative ophthalmology & visual science · 2014Article
- Mathematical modeling approaches in the study of glaucoma disparities among people of African and European descents.Journal of coupled systems and multiscale dynamics · 2013Article
- Human lamina cribrosa insertion and age.Investigative ophthalmology & visual science · 2012Article
- A few good responses: which mechanical effects of IOP on the ONH to study?Investigative ophthalmology & visual science · 2012Article
- The optic nerve head as a robust biomechanical system.Investigative ophthalmology & visual science · 2012Article
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Authors and funding
1 author.
Funding
Abstract
purposeThe ability to predict the biomechanical response of the optic nerve head (ONH) to intraocular pressure (IOP) elevation holds great promise, yet remains elusive. The objective of this work was to introduce an approach to model ONH biomechanics that combines the ease of use and speed of analytical models with the flexibility and power of numerical models.
methodsModels representing a variety of ONHs were produced, and finite element (FE) techniques used to predict the stresses (forces) and strains (relative deformations) induced on each of the models by IOP elevations (up to 10 mm Hg). Multivariate regression was used to parameterize each biomechanical response as an analytical function. These functions were encoded into a Flash-based applet. Applet utility was demonstrated by investigating hypotheses concerning ONH biomechanics posited in the literature.
resultsAll responses were parameterized well by polynomials (R² values between 0.985 and 0.999), demonstrating the effectiveness of our fitting approach. Previously published univariate results were reproduced with the applet in seconds. A few minutes allowed for multivariate analysis, with which it was predicted that often, but not always, larger eyes experience higher levels of stress and strain than smaller ones, even at the same IOP.
conclusionsAn applet has been presented with which it is simple to make rapid estimates of IOP-related ONH biomechanics. The applet represents a step toward bringing the power of FE modeling beyond the specialized laboratory and can thus help develop more refined biomechanics-based hypotheses. The applet is available for use at www.ocularbiomechanics.com.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.