ArticleDevelopmental and comparative immunology2011
Lipopolysaccharide enhances bactericidal activity in Dictyostelium discoideum cells.
Article in Developmental and comparative immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- Quantitative Analysis of the Inactivation Process of Internalized Bacteria in Dictyostelium Cells.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Origins, Biology, and Diseases of Tissue Macrophages.Annual review of immunology · 2021Review
- Article
- The origin and evolution of cell-intrinsic antibacterial defenses in eukaryotes.Current opinion in genetics & development · 2019Review
- Lipid A Remodeling Is a Pathoadaptive Mechanism That Impacts Lipopolysaccharide Recognition and Intracellular Survival of Burkholderia pseudomallei.Infection and immunity · 2018Article
- Lipopolysaccharide Detection across the Kingdoms of Life.Trends in immunology · 2017Review
- Detecting, visualizing and quantitating the generation of reactive oxygen species in an amoeba model system.Journal of visualized experiments : JoVE · 2013Article
- Bacterial discrimination by dictyostelid amoebae reveals the complexity of ancient interspecies interactions.Current biology : CB · 2013Article
- Lipopolysaccharide induction of autophagy is associated with enhanced bactericidal activity in Dictyostelium discoideum.Biochemical and biophysical research communications · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Innate immune cells respond to invading microbes upon detection of pathogen-associated molecular patterns (PAMPS). PAMP-recognition machinery is evolutionarily conserved, allowing for characterization in model organisms. The model organism Dictyostelium discoideum can exist as single-celled amoebae, which phagocytize bacteria for nutrients. Although D. discoideum is used extensively to study phagocytosis, it has not been determined if D. discoideum detects bacterial PAMPs using pattern-recognition machinery. Here we show that D. discoideum mounts responses against the bacterial cell wall PAMP, lipopolysaccharide (LPS). Upon treatment with LPS or its active component Lipid A, D. discoideum cells more efficiently clear phagocytized bacteria. LPS-enhanced bactericidal activity appears dependent both on MAPK signaling pathways as well as on the D. discoideum toll/interleukin-1 receptor domain-containing protein, TirA. These findings indicate that pattern-recognition machinery required to detect and respond to bacterial PAMPs may be conserved in D. discoideum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.