ArticleDevelopmental biology2011
Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- The Hippo effector TEAD1 regulates postnatal murine cerebellar development.Brain structure & function · 2025Article
- Decoding YAP dependent transcription in the liver.Nucleic acids research · 2022Article
- An overview of signaling pathways regulating YAP/TAZ activity.Cellular and molecular life sciences : CMLS · 2021Review
- VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle.Journal of cell science · 2019Article
- Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression.Scientific reports · 2018Article
- Effect of TEAD4 on multilineage differentiation of muscle-derived stem cells.American journal of translational research · 2018Article
- Myogenic progenitor specification from pluripotent stem cells.Seminars in cell & developmental biology · 2017Review
- TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo.PLoS genetics · 2017Article
- The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma.The Journal of pathology · 2016Article
- Concise Review: Epigenetic Regulation of Myogenesis in Health and Disease.Stem cells translational medicine · 2016Review
- YAP-Mediated Mechanotransduction in Skeletal Muscle.Frontiers in physiology · 2016Review
- Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer.Biology open · 2015Article
- The mammalian Hippo pathway: regulation and function of YAP1 and TAZ.Cellular and molecular life sciences : CMLS · 2015Review
- Functional effect of mir-27b on myostatin expression: a relationship in Piedmontese cattle with double-muscled phenotype.BMC genomics · 2013Article
- The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells.Journal of cell science · 2012Article
- Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs.Developmental cell · 2012Article
- Musculin and TCF21 coordinate the maintenance of myogenic regulatory factor expression levels during mouse craniofacial development.Development (Cambridge, England) · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The transcriptional regulation of the Mrf4/Myf5 locus depends on a multitude of enhancers that, in equilibria with transcription balancing sequences and the promoters, regulate the expression of the two genes throughout embryonic development and in the adult. Transcription in a particular set of muscle progenitors can be driven by the combined outputs of several enhancers that are not able to recapitulate the entire expression pattern in isolation, or by the action of a single enhancer the activity of which in isolation is equivalent to that within the context of the locus. We identified a new enhancer element of this second class, ECR111, which is highly conserved in all vertebrate species and is necessary and sufficient to drive Myf5 expression in ventro-caudal and ventro-rostral somitic compartments in the mouse embryo. EMSA analyses and data obtained from binding-site mutations in transgenic embryos show that a binding site for a TEA Domain (TEAD) transcription factor is essential for the function of this new enhancer, while ChIP assays show that at least two members of the family of transcription factors bind to it in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.