ArticleJournal of the American College of Cardiology2011
A prospective study of muscular strength and all-cause mortality in men with hypertension.
Article in Journal of the American College of Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 4 syntheses or guidelines pooled it, 239 citations in OpenAlex.
- The neglected association between central obesity markers and abdominal aortic aneurysm presence: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Pooled it
- Is resistance training alone an antihypertensive therapy? A meta-analysis.Journal of human hypertension · 2021Pooled it
- The Minimum Effective Training Dose Required to Increase 1RM Strength in Resistance-Trained Men: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Resistance training alone reduces systolic and diastolic blood pressure in prehypertensive and hypertensive individuals: meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Pooled it
- Chocolate Milk versus carbohydrate supplements in adolescent athletes: a field based study.Journal of the International Society of Sports Nutrition · 2019Trial
- Acute effects of different resistance training loads on cardiac autonomic modulation in hypertensive postmenopausal women.Journal of translational medicine · 2018Trial
- The influence of resting blood pressure on muscle strength in healthy adults.Blood pressure monitoring · 2018Trial
- Psychosocial mediators of a theory-based resistance training maintenance intervention for prediabetic adults.Psychology & health · 2016Trial
- Effect of resistance training with different frequencies and detraining on muscular strength and oxidative stress biomarkers in older women.Age (Dordrecht, Netherlands) · 2015Trial
- Trial
- Effects of whole-body vibration exercise training on aortic wave reflection and muscle strength in postmenopausal women with prehypertension and hypertension.Journal of human hypertension · 2014Trial
- Sustained effect of resistance training on blood pressure and hand grip strength following a detraining period in elderly hypertensive women: a pilot study.Clinical interventions in aging · 2014Trial
- Trial
- Association between body mass index and survival outcomes for in-hospital cardiac arrest.Resuscitation · 2025Article
- The effect of different proximities to failure on arterial stiffness following resistance training protocols matched for volume-load.Physiological reports · 2025Article
- Combining muscle strengthening activity and aerobic exercise: a prescription for better health in patients with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Associations of sugar-sweetened beverage consumption and screen time with physical fitness index: a multicentre cross-sectional study among Chinese adolescents.BMC public health · 2024Article
- Sex differences of the association between handgrip strength and health-related quality of life among patients with cancer.Scientific reports · 2024Article
- Differences in the Levels of Physical Activity and Sport Habits between Men and Women in Cartagena (Spain).Sports (Basel, Switzerland) · 2024Article
- Effects of chemotherapy treatment on muscle strength indicators, functional capacity and biopsychosocial aspects of women with breast cancer.American journal of cancer research · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
objectivesThis study sought to assess the impact of muscular strength on mortality in men with hypertension.
backgroundMuscular strength is inversely associated with mortality in healthy men, but this association has not been examined in men with hypertension.
methodsWe followed 1,506 hypertensive men age 40 years and older enrolled in the Aerobics Center Longitudinal Study from 1980 to 2003. Participants received an extensive medical examination at baseline. Muscular strength was quantified by combining 1 repetition maximum (1-RM) measures for leg and bench press and cardiorespiratory fitness assessed by maximum exercise test on a treadmill.
resultsDuring an average follow-up of 18.3 years, 183 deaths occurred. Age-adjusted death rates per 10,000 person-years across incremental thirds of muscular strength were 81.8, 65.5, and 52.0 (p < 0.05 for linear trend). Multivariable Cox regression hazard ratios were 1.0 (reference), 0.81 (95% confidence interval [CI]: 0.57 to 1.14), and 0.59 (95% CI: 0.40 to 0.86) across incremental thirds of muscular strength. After further adjustment for cardiorespiratory fitness, those participants in the upper third of muscular strength still had a lower risk of death (hazard ratio [HR]: 0.66; 95% CI: 0.45 to 0.98). In the muscular strength and CRF combined analysis, men simultaneously in the upper third of muscular strength and high fitness group had the lowest mortality risk among all combination groups (HR: 0.49; 95% CI: 0.30 to 0.82), with men in the lower third of muscular strength and low fitness group as reference.
conclusionsHigh levels of muscular strength appear to protect hypertensive men against all-cause mortality, and this is in addition to the benefit provided by cardiorespiratory fitness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.